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http://hdl.handle.net/2445/171571
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DC Field | Value | Language |
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dc.contributor.author | Fusté, Noel P. | - |
dc.contributor.author | Guasch, M. | - |
dc.contributor.author | Guillen, P. | - |
dc.contributor.author | Anerillas, C. | - |
dc.contributor.author | Cemeli, T. | - |
dc.contributor.author | Pedraza, N. | - |
dc.contributor.author | Ferrezuelo, F. | - |
dc.contributor.author | Encinas, M. | - |
dc.contributor.author | Moralejo, M. | - |
dc.contributor.author | Garí, Eloi | - |
dc.date.accessioned | 2020-10-28T07:36:20Z | - |
dc.date.available | 2020-10-28T07:36:20Z | - |
dc.date.issued | 2019-04-15 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171571 | - |
dc.description.abstract | β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. We have determined that this transitory arrest was dependent on the cell-cycle regulator protein Retinoblastoma. Moreover, dermal fibroblasts increase their migration capacities at 24 h after barley β-glucan addition. Also, we have described that barley β-glucan strongly reduced the ability of fibroblasts to attach and to spread on cell plates. Our data indicates that barley β-glucan signal induces an early response in HDF cells favoring migration versus proliferation. This feature is consistent with our observation that the topical addition of our barley β-glucan in vivo accelerates the wound closure in mouse skin. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Science Ltd. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.carbpol.2019.01.090 | - |
dc.relation.ispartof | Carbohydrate Polymers, 2019, vol. 210, p. 389-398 | - |
dc.relation.uri | https://doi.org/10.1016/j.carbpol.2019.01.090 | - |
dc.rights | cc by-nc-nd (c) Fusté et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Polisacàrids | - |
dc.subject.classification | Fibroblasts | - |
dc.subject.other | Polysaccharides | - |
dc.subject.other | Fibroblasts | - |
dc.title | Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-10-26T09:21:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30732776 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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FusteNP.pdf | 2.08 MB | Adobe PDF | View/Open |
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