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Title: Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition
Author: Park, Jing Young
Bueno de Mesquita, H. Bas
Ferrari, Pietro
Weiderpass, Elisabete
Batlle, Jordi de
Tjønneland, Anne
Kyro, Cecilie
Rebours, Vinciane
Boutron-Ruault, Marie-Christine
Mancini, Francesca Romana
Katzke, Verena
Kuhn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
La Vecchia, Carlo
Kritikou, Maria
Masala, Giovanna
Pala, Valeria
Tumino, Rosario
Panico, Salvatore
Peeters, Petra H.
Skeie, Guri
Merino, Susana
Duell, Eric J.
Rodríguez Barranco, Miguel
Dorronsoro, Miren
Chirlaque, María Dolores
Ardanaz, Eva
Gylling, Björn
Schneede, Jörn
Ericson, Ulrika
Sternby, Hanna
Khaw, Kay Tee
Bradbury, Kathryn E.
Huybrechts, Inge
Aune, Dagfinn
Vineis, Paolo
Slimani, Nadia
Keywords: Càncer de pàncrees
Assaigs clínics
Pancreas cancer
Clinical trials
Issue Date: 1-Apr-2019
Publisher: Wiley
Abstract: Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (>= 353 mu g/day) compared to the lowest (<241 mu g/day) was 0.81 (95% CI: 0.51, 1.31; p(trend) = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for >= 353 mu g/day vs. <241 mu g/day, p(trend) = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p(interaction) = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
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It is part of: International Journal Of Cancer, 2019-04-01, Vol. 144, Issue 7, P. 1511-1521
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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