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Title: | Editorial: Purinergic Pharmacology |
Author: | Ciruela Alférez, Francisco Jacobson, Kenneth A. |
Keywords: | Proteïnes G Neurociències G Proteins Neurosciences |
Issue Date: | 23-Jan-2019 |
Publisher: | Frontiers Media |
Abstract: | The purine nucleotides and nucleosides constitute important extracellular signaling molecules acting as neurotransmitters and neuromodulators. Indeed, extracellular adenosine 5′-triphosphate (ATP) and adenosine, tightly controlled by nucleotidases, ribokinases, deaminases, and transporters, signal through a rich array of purinergic receptors. These receptors, which emerged early in evolution, are among the most abundant in living organisms controlling many physiological actions, thus becoming promising therapeutic targets in a wide range of pathological conditions. Thus, while P1 receptors are selective for adenosine, a breakdown product of ATP, P2 receptors are activated by purine nucleotides, as well as P2Y receptors being activated by pyrimidine nucleotides. Interestingly, purinergic receptors, both G protein-coupled (i.e., P1 and P2Y) and ligand-gated ion channel (i.e., P2X) receptors, are involved in many neuronal and non-neuronal mechanisms, including pain, immune responses, exocrine and endocrine secretion, platelet aggregation, endothelial-mediated vasodilatation and inflammation, among others. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fphar.2019.00021 |
It is part of: | Frontiers In Pharmacology, 2019-01-23, Vol. 10, art. 21 |
URI: | http://hdl.handle.net/2445/171593 |
Related resource: | https://doi.org/10.3389/fphar.2019.00021 |
Appears in Collections: | Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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