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Title: | Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment |
Author: | Georgouli, Mirella Herraiz, Cecilia Crosas Molist, Eva Fanshawe, Bruce Maiques, Oscar Perdrix Rosell, Anna Pandya, Pahini Rodríguez Hernández, Irene Ilieva, Kristina M. Cantelli, Gaia Karagiannis, Panagiotis Mele, Silvia Lam, Hoyin Josephs, Debra H. Matias-Guiu, Xavier Marti, Rosa M. Nestle, Frank O. Orgaz, Jose L. Malanchi, Ilaria Fruhwirth, Gilbert O. Karagiannis, Sophia N. Sanz Moreno, Victoria |
Keywords: | Càncer Melanoma Metàstasi Cancer Metastasis |
Issue Date: | 7-Feb-2019 |
Publisher: | Cell Press |
Abstract: | ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206(+)CD163(+) tumor-associated macrophages and vessels. Proteomic analysis shows that ROCK Myosin II activity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and their differentiation into tumor-promoting macrophages. Both amoeboid cancer cells and their associated macrophages support an abnormal vasculature, which ultimately facilitates tumor progression. Mechanistically, amoeboid cancer cells perpetuate their behavior via ROCK-Myosin II-driven IL-alpha secretion and NF-kappa B activation. Using an array of tumor models, we show that high Myosin II activity in tumor cells reprograms the innate immune microenvironment to support tumor growth. We describe an unexpected role for Myosin II dynamics in cancer cells controlling myeloid function via secreted factors. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.cell.2018.12.038 |
It is part of: | Cell, 2019-02-07, Vol. 176, Issue 4, P. 757-774 |
URI: | http://hdl.handle.net/2445/171669 |
Related resource: | https://doi.org/10.1016/j.cell.2018.12.038 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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