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Title: Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study
Author: Brenner, Darren R.
Fehringer, Gord
Zhang, Zuo-Feng
Lee, Yuan-Chin
Meyers, Travis
Matsuo, Keitaro
Ito, Hidemi
Vineis, Paolo
Stucker, Isabelle
Boffetta, Paolo
Brennan, Paul
Christiani, David C.
Diao, Nancy
Hong, Yun-Chul
Landi, Maria T.
Morgenstern, Hal
Schwartz, Ann G.
Rennert, Gad
Saliba, Walid
Mclaughlin, John R.
Harris, Curtis C.
Orlow, Irene
Barros Dios, Juan M.
Ruano Raviña, Alberto
Siemiatycki, Jack
Koushik, Anita
Coté, Michele L.
Lazarus, Philip
Fernández Tardón, Guillermo
Tardón, Adonina
Marchand, Loic Le
Brenner, Hermann
Saum, Kai-Uwe
Duell, Eric J.
Andrew, Angeline S.
Consonni, Dario
Olsson, Ann
Hung, Rayjean J.
Straif, Kurt
Keywords: Càncer de pulmó
Lung cancer
Issue Date: 1-Feb-2019
Publisher: Elsevier Sci Ltd
Abstract: Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for >= 20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.
Note: Versió postprint del document publicat a:
It is part of: Cancer Epidemiology, 2019-02-01, Vol. 58, P. 25-32
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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