Please use this identifier to cite or link to this item:
Title: Implication of voltage-gated potassium channels in neoplastic cell proliferation
Author: Serrano Novillo, Clara
Capera Aragonés, Jesusa
Colomer-Molera, Magalí
Condom i Mundó, Enric
Ferreres, Joan C.
Felipe Campo, Antonio
Keywords: Càncer
Cicle cel·lular
Proliferació cel·lular
Cell cycle
Cell proliferation
Issue Date: 1-Mar-2019
Publisher: MDPI
Abstract: Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2019, vol. 11, num. 3, p. 287
Related resource:
ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
691797.pdf2.56 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons