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http://hdl.handle.net/2445/171734
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DC Field | Value | Language |
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dc.contributor.author | Grillo, Sara | - |
dc.contributor.author | Cuervo Requena, Guillermo | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | Grau, Immaculada | - |
dc.contributor.author | Llaberia, Mariona | - |
dc.contributor.author | Aguado, José María | - |
dc.contributor.author | López Cortés, Luis Eduardo | - |
dc.contributor.author | Lalueza, Antonio | - |
dc.contributor.author | Sanjuan, Rafael | - |
dc.contributor.author | Sanchez Batanero, Ana | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.contributor.author | García Somoza, Dolors | - |
dc.contributor.author | Tebé, Cristian | - |
dc.contributor.author | Pujol Rojo, Miquel | - |
dc.date.accessioned | 2020-11-03T18:14:02Z | - |
dc.date.available | 2020-11-03T18:14:02Z | - |
dc.date.issued | 2020-07-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171734 | - |
dc.description.abstract | Background. Staphylococcus aureus bloodstream infection (SABSI) arising from a urinary tract source (UTS) is poorly understood. Methods. We conducted a retrospective analysis in 3 major teaching hospitals in Spain of prospectively collected data of hospitalized patients with SABSI. SABSI-UTS was diagnosed in patients with urinary tract symptoms and/or signs, no evidence of an extra-urinary source of infection, and a urinary S. aureus count of >= 10(5) cfu/mL. Susceptibility of S. aureus strains and patient mortality were compared between SABSI from UTS (SABSI-UTS) and other sources (SABSI-other). Results. Of 4181 episodes of SABSI, we identified 132 (3.16%) cases of SABSI-UTS that occurred predominantly in patients who were male, had high Charlson comorbidity scores, were dependent for daily life activities, and who had undergone urinary catheterization and/or urinary manipulation before the infection. SABSI-UTS was more often caused by MRSA strains compared with SABSI-other (40.9% vs 17.5%; P < .001). Patients with SABSI-UTS caused by MRSA more often received inadequate empirical treatment compared with those caused by susceptible strains (59.7% vs 23.1%; P < .001). The 30-day case fatality rate was lower in patients with SABSI-UTS than in those with SABSI-other (14.4% vs 23.8%; P = .02). Factors independently associated with mortality were dependence for daily activities (aOR, 3.877; 95% CI, 1.08-13.8; P = .037) and persistent bacteremia (aOR, 7.88; 95% CI, 1.57-39.46; P = .012). Conclusions. SABSI-UTS occurs predominantly in patients with severe underlying conditions and in those who have undergone urinary tract manipulation. Moreover, it is frequently due to MRSA strains and causes significant mortality. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/ofid/ofaa216 | - |
dc.relation.ispartof | Open Forum Infectious Diseases, 2020, vol. 7, num. 7 | - |
dc.relation.uri | https://doi.org/10.1093/ofid/ofaa216 | - |
dc.rights | cc by-nc-nd (c) Grillo et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Infeccions per estafilococs | - |
dc.subject.classification | Aparell urinari | - |
dc.subject.other | Staphylococcal infections | - |
dc.subject.other | Urinary organs | - |
dc.title | Characteristics and Outcomes of Staphylococcus aureus Bloodstream Infection Originating From the Urinary Tract: A Multicenter Cohort Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-11-03T17:08:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32665958 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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GrilloS.pdf | 442.32 kB | Adobe PDF | View/Open |
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