Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171793
Title: Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
Author: Alustiza, Miren
Hernández Illán, Eva
Juárez, Miriam
Giner Calabuig, Mar
Mira, Cristina
Martínez Roca, Alejandro
Bujanda, Luis
Rodríguez Moranta, Francisco
Cubiella, Joaquín
Castro, Luisa de
Marín Gabriel, José Carlos
Herreros de tejada, Alberto
Fernández Bañares, Fernando
Nicolás Pérez, David
Giménez, Paula
Martínez Cardona, Claudia
Francés, Rubé
Murcia, Oscar
Jover, Rodrigo
Keywords: Pòlips (Patologia)
Citoquines
Polyps (Pathology)
Cytokines
Issue Date: 1-Mar-2020
Publisher: Lippincott Williams & Wilkins
Abstract: OBJECTIVES: Most patientswith multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multiple colonic polyps. METHODS: Eighty-three patients with 10 or more adenomatous or serrated polyps and 53 control people with normal colonoscopy were included. Smoking habits were registered, and glucose, CRP, and basal insulin in the serum/blood weremeasured. Quantification of IL-2, IL-4, IL-6, IL-10, IL-11, IL-17A, and IL-23 cytokine levels in the serum was performed by a high-sensitivity enzyme-linked immunosorbent assay. RESULTS: Smoking and diabetesweremore prevalent in those with colonic polyps than in the control people (67% vs 16%, P = 0.001; 11% vs 2%, P = 0.048). In addition, the cytokine serum levels were higher, i.e., IL-2 (P = 0.001), IL-4 (P = 0.001), IL-6 (P = 0.001), IL-17A (P = 0.001), IL-23 (P = 0.014), and CRP (P = 0.003). Adjusting for sex, smoking, and diabetes in amultivariate analysis, IL-2, IL-4, IL-6, IL-17A, and IL-23 remained independently elevated in cases with multiple polyps. DISCUSSION: These results indicate that immune responses mediated by Th17 cells may be involved in the pathogenesis of multiple colonic polyps.
Note: Reproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000143
It is part of: Clinical and Translational Gastroenterology, 2020, vol. 11
URI: http://hdl.handle.net/2445/171793
Related resource: https://doi.org/10.14309/ctg.0000000000000143
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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