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http://hdl.handle.net/2445/171793
Title: | Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin |
Author: | Alustiza, Miren Hernández Illán, Eva Juárez, Miriam Giner Calabuig, Mar Mira, Cristina Martínez Roca, Alejandro Bujanda, Luis Rodríguez Moranta, Francisco Cubiella, Joaquín Castro, Luisa de Marín Gabriel, José Carlos Herreros de tejada, Alberto Fernández Bañares, Fernando Nicolás Pérez, David Giménez, Paula Martínez Cardona, Claudia Francés, Rubé Murcia, Oscar Jover, Rodrigo |
Keywords: | Pòlips (Patologia) Citoquines Polyps (Pathology) Cytokines |
Issue Date: | 1-Mar-2020 |
Publisher: | Lippincott Williams & Wilkins |
Abstract: | OBJECTIVES: Most patientswith multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multiple colonic polyps. METHODS: Eighty-three patients with 10 or more adenomatous or serrated polyps and 53 control people with normal colonoscopy were included. Smoking habits were registered, and glucose, CRP, and basal insulin in the serum/blood weremeasured. Quantification of IL-2, IL-4, IL-6, IL-10, IL-11, IL-17A, and IL-23 cytokine levels in the serum was performed by a high-sensitivity enzyme-linked immunosorbent assay. RESULTS: Smoking and diabetesweremore prevalent in those with colonic polyps than in the control people (67% vs 16%, P = 0.001; 11% vs 2%, P = 0.048). In addition, the cytokine serum levels were higher, i.e., IL-2 (P = 0.001), IL-4 (P = 0.001), IL-6 (P = 0.001), IL-17A (P = 0.001), IL-23 (P = 0.014), and CRP (P = 0.003). Adjusting for sex, smoking, and diabetes in amultivariate analysis, IL-2, IL-4, IL-6, IL-17A, and IL-23 remained independently elevated in cases with multiple polyps. DISCUSSION: These results indicate that immune responses mediated by Th17 cells may be involved in the pathogenesis of multiple colonic polyps. |
Note: | Reproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000143 |
It is part of: | Clinical and Translational Gastroenterology, 2020, vol. 11 |
URI: | http://hdl.handle.net/2445/171793 |
Related resource: | https://doi.org/10.14309/ctg.0000000000000143 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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