Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171823
Title: Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia
Author: Llorens Torres, Franc
Hermann, Peter
Villar Piqué, Anna
Diaz Lucena, Daniela
Nägga, Katarina
Hansson, Oskar
Santana, Isabel
Schmitz, Matthias
Schmidt, Christian
Varges , Daniela
Goebel, Stefan
Dumurgier, Julien
Zetterberg, Henrik
Blennow, Kaj
Paquet, Claire
Baldeiras, Inês
Ferrer, Isidro (Ferrer Abizanda)
Zerr, Inga
Keywords: Demència
Marcadors bioquímics
Dementia
Biochemical markers
Issue Date: 30-Jan-2020
Publisher: Nature Publishing Group
Abstract: The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer's disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-14373-2
It is part of: Nature Communications, 2020, vol. 11, p. 619
URI: http://hdl.handle.net/2445/171823
Related resource: https://doi.org/10.1038/s41467-020-14373-2
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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