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DC Field | Value | Language |
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dc.contributor.author | Schmit, Stephanie L. | - |
dc.contributor.author | Edlund, Christopher K. | - |
dc.contributor.author | Schumacher, Fredrick R. | - |
dc.contributor.author | Gong, Jian | - |
dc.contributor.author | Harrison, Tabitha A. | - |
dc.contributor.author | Huyghe, Jeroen R. | - |
dc.contributor.author | Qu, Chenxu | - |
dc.contributor.author | Van Den Berg, David J. | - |
dc.contributor.author | Wang, Hansong | - |
dc.contributor.author | Tring, Stephanie | - |
dc.contributor.author | Plummer, Sarah J. | - |
dc.contributor.author | Melas, Marilena | - |
dc.contributor.author | Riggs, Bridget M. | - |
dc.contributor.author | Schoen, Robert E. | - |
dc.contributor.author | English, Dallas R. | - |
dc.contributor.author | Zubair, Niha | - |
dc.contributor.author | Gonzalez Villalpando, Clicerio | - |
dc.contributor.author | Huang, Shu-Chen | - |
dc.contributor.author | Wu, Anna H. | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Iwasaki, Motoki | - |
dc.contributor.author | Chin, Lee Soo | - |
dc.contributor.author | Fortini, Barbara K. | - |
dc.contributor.author | Stadler, Zsofia K. | - |
dc.contributor.author | Huerta Castaño, José María | - |
dc.contributor.author | Ma, Jing | - |
dc.contributor.author | Paredes Cotoré, Jesus P. | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | Newcomb, Polly A. | - |
dc.contributor.author | Cheng, Iona | - |
dc.contributor.author | Sellers, Thomas A. | - |
dc.contributor.author | Grady, William M. | - |
dc.contributor.author | Fuchs, Charles S. | - |
dc.contributor.author | Virtamo, Jarmo | - |
dc.contributor.author | Gala, Manish | - |
dc.contributor.author | Idos, Gregory E. | - |
dc.contributor.author | Cotterchio, Michelle | - |
dc.contributor.author | Hayes, Richard B. | - |
dc.contributor.author | Lin, Yi | - |
dc.contributor.author | Lu, Yingchang | - |
dc.contributor.author | Stern, Mariana C. | - |
dc.contributor.author | Loupakis, Fotios | - |
dc.contributor.author | Laurie, Cecelia A. | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Figueiredo, Jane C. | - |
dc.contributor.author | McDonnell, Kevin J. | - |
dc.contributor.author | Gruber, Stephen B. | - |
dc.contributor.author | Schafmayer, Clemens | - |
dc.contributor.author | Bien, Stephanie A. | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Berndt, Sonja I. | - |
dc.contributor.author | Lenz, Heinz-Josef | - |
dc.contributor.author | Siegel, Erin M. | - |
dc.contributor.author | Jackson, Rebecca D. | - |
dc.contributor.author | Thomas, Duncan C. | - |
dc.contributor.author | Tsugane, Shoichiro | - |
dc.contributor.author | Arndt, Volker | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Hampe, Jochen | - |
dc.contributor.author | Zanke, Brent W. | - |
dc.contributor.author | Levine, David | - |
dc.contributor.author | Carlson, Christopher S. | - |
dc.contributor.author | Lejbkowicz, Flavio | - |
dc.contributor.author | Seminara, Daniela | - |
dc.contributor.author | Li, Christopher I. | - |
dc.contributor.author | Woods, Michael | - |
dc.contributor.author | Marchand, Loïc Le | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Li, Li | - |
dc.contributor.author | Anton, Kristen | - |
dc.contributor.author | Matsuo, Keitaro | - |
dc.contributor.author | Duggan, David | - |
dc.contributor.author | Stintzing, Sebastian | - |
dc.contributor.author | Church, Timothy R. | - |
dc.contributor.author | Shu, Xiao-Ou | - |
dc.contributor.author | Coetzee, Gerhard A. | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | Castelao, Jose E. | - |
dc.contributor.author | Lieb, Wolfgang | - |
dc.contributor.author | Thibodeau, Stephen N. | - |
dc.contributor.author | Jacobs, Eric J. | - |
dc.contributor.author | Raskin, Leon | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Zhang, Ben | - |
dc.contributor.author | Caan, Bette J. | - |
dc.contributor.author | Potter, John D. | - |
dc.contributor.author | Curtis, Keith R. | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Chan, Andrew T. | - |
dc.contributor.author | LaCroix, Andrea | - |
dc.contributor.author | Win, Aung Ko | - |
dc.contributor.author | Gogarten, Stephanie M. | - |
dc.contributor.author | Rennert, Hedy S. | - |
dc.contributor.author | Casey, Graham | - |
dc.contributor.author | Matsuda, Koichi | - |
dc.contributor.author | Slattery, Martha L. | - |
dc.contributor.author | Harju, John F. | - |
dc.contributor.author | Barry, Elizabeth L. | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Kolonel, Laurence N. | - |
dc.contributor.author | Alonso Aguado, Maria Henar | - |
dc.contributor.author | Jiao, Shuo | - |
dc.contributor.author | Pharoah, Paul D. | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Campbell, Peter T. | - |
dc.contributor.author | Markowitz, Sanford D. | - |
dc.contributor.author | Mancao, Christoph | - |
dc.contributor.author | Correa, Marcia Cruz | - |
dc.contributor.author | Bézieau, Stéphane | - |
dc.contributor.author | Feskens, Edith J. M. | - |
dc.contributor.author | Gsur, Andrea | - |
dc.contributor.author | Brezina, Stefanie | - |
dc.contributor.author | Kweon, Sun-Seog | - |
dc.contributor.author | Liu, Yun-Ru | - |
dc.contributor.author | Xiang, Yong-Bing | - |
dc.contributor.author | Hudson, Thomas J. | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Ulrich, Cornelia M. | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Luh, Frank | - |
dc.contributor.author | Boehm, Juergen | - |
dc.contributor.author | Mukherjee, Bhramar | - |
dc.contributor.author | Trichopoulou, Antonia | - |
dc.contributor.author | Qu, Conghui | - |
dc.contributor.author | Manion, Frank J. | - |
dc.contributor.author | Gauderman, W. James | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Shi, Wei | - |
dc.contributor.author | Greenson, Joel K. | - |
dc.contributor.author | Bloomer, Amanda | - |
dc.contributor.author | van Duijnhoven, Franzel J. B. | - |
dc.contributor.author | Conti, David V. | - |
dc.contributor.author | Rennert, Gad | - |
dc.contributor.author | Jenkins, Mark A. | - |
dc.contributor.author | Wu, Kana | - |
dc.contributor.author | Aragaki, Aaron K. | - |
dc.contributor.author | Taverna, Darin | - |
dc.contributor.author | Lindor, Noralane M. | - |
dc.contributor.author | Harlid, Sophia | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Kono, Suminori | - |
dc.contributor.author | Molina de la Torre, Antonio José | - |
dc.contributor.author | Buchanan, Daniel D. | - |
dc.contributor.author | Gunter, Marc | - |
dc.contributor.author | Jia, Wei-Hua | - |
dc.contributor.author | McNeil, Caroline E. | - |
dc.contributor.author | Wolk, Alicja | - |
dc.contributor.author | Jee, Sun Ha | - |
dc.contributor.author | Weinstein, Stephanie J. | - |
dc.contributor.author | Zeng, Yi-Xin | - |
dc.contributor.author | White, Emily | - |
dc.contributor.author | Joshi, Amit D. | - |
dc.contributor.author | Butterbach, Katja | - |
dc.contributor.author | Gonzalez Villalpando, Elena M. | - |
dc.contributor.author | Fischer, Rocky | - |
dc.contributor.author | Omichessan, Hanane | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Shibata, David | - |
dc.contributor.author | Hoffmeister, Michael | - |
dc.contributor.author | Lindblom, Annika | - |
dc.contributor.author | Lemire, Mathieu | - |
dc.contributor.author | Fritsche, Lars G. | - |
dc.contributor.author | Church, James M. | - |
dc.contributor.author | Martín Sánchez, Vicente | - |
dc.contributor.author | van Guelpan, Bethany | - |
dc.contributor.author | Pérez-Mayoral, Julyann | - |
dc.contributor.author | Gago-Dominguez, Manuela | - |
dc.contributor.author | FitzGerald, Liesel M. | - |
dc.contributor.author | Krogh, Vittorio | - |
dc.contributor.author | Severi, Gianluca | - |
dc.contributor.author | Yen, Yun | - |
dc.contributor.author | Vijai, Joseph | - |
dc.contributor.author | Peters, Ulrike | - |
dc.contributor.author | Kuehn, Tilman | - |
dc.contributor.author | Küry, Sébastien | - |
dc.contributor.author | Cheng, Ya-Wen | - |
dc.contributor.author | Southey, Melissa | - |
dc.contributor.author | Hsu, Li | - |
dc.contributor.author | Giovannucci, Edward L. | - |
dc.contributor.author | Kooperberg, Charles | - |
dc.contributor.author | Hofer, Philipp | - |
dc.date.accessioned | 2020-11-12T12:11:46Z | - |
dc.date.available | 2020-11-12T12:11:46Z | - |
dc.date.issued | 2018-06-16 | - |
dc.identifier.issn | 0027-8874 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171985 | - |
dc.description.abstract | BACKGROUND: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk. METHODS: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided. RESULTS: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0. CONCLUSIONS: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1093/jnci/djy099 | - |
dc.relation.ispartof | JNCI: Journal of The National Cancer Institute, 2018, vol. 111, num. 2, p. 146-157 | - |
dc.relation.uri | https://doi.org/10.1093/jnci/djy099 | - |
dc.rights | (c) Schmit, Stephanie L. et al., 2018 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Genètica | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Genetics | - |
dc.title | Novel Common Genetic Susceptibility Loci for Colorectal Cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 685303 | - |
dc.date.updated | 2020-11-12T12:11:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29917119 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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685303.pdf | 350.79 kB | Adobe PDF | View/Open |
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