Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172028
Title: The rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy and safety of an active strategy for the diagnosis and treatment of acute pulmonary embolism during exacerbations of chronic obstructive pulmonary disease
Author: Jiménez, David
Agustí García-Navarro, Àlvar
Monreal, Manuel
Otero, Remedios
Huisman, Menno V.
Lobo, José L.
Quezada, Andrés
Jara-Palomares, Luis
Hernando, Ascensión
Tabernero, Eva
Marcos, Pedro
Ruiz-Artacho, Pedro
Ballaz, Aitor
Bertoletti, Laurent
Couturaud, Francis
Yusen, Roger
Keywords: Malalties dels pulmons
Embòlia pulmonar
Terapèutica
Pulmonary diseases
Pulmonary embolism
Therapeutics
Issue Date: 1-Mar-2019
Publisher: Wiley
Abstract: Introduction: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs usual care) in patients hospitalized because of ECOPD. Methods: SLICE is a phase III, prospective, international, multicenter, randomized, open-label, and parallel-group trial. A total of 746 patients hospitalized because of ECOPD will be randomized in a 1:1 fashion to receive either an active strategy for the diagnosis and anticoagulant treatment of PE or usual care (ie, standard care without any diagnostic test for diagnosing PE). The primary outcome is a composite of all-cause death, non-fatal (recurrent) venous thromboembolism (VTE), or readmission for ECOPD within 90 days after enrollment. Secondary outcomes are (a) death from any cause within 90 days after enrollment, (b) non-fatal (recurrent) VTE within 90 days after enrollment, (c) readmission within 90 days after enrollment, and (d) length of hospital stay. Results: Enrollment started in September 2014 and is expected to proceed until 2020. Median age of the first 443 patients was 71 years (interquartile range, 64-78), and 26% were female. Conclusions: This multicenter trial will determine the value of detecting PEs in patients with ECOPD. This has implications for COPD patient morbidity and mortality.
Note: Reproducció del document publicat a: https://doi.org/10.1002/clc.23161
It is part of: Clinical Cardiology, 2019, vol. 42, num. 3, p. 346-351
URI: http://hdl.handle.net/2445/172028
Related resource: https://doi.org/10.1002/clc.23161
ISSN: 0160-9289
Appears in Collections:Articles publicats en revistes (Medicina)

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