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http://hdl.handle.net/2445/172030
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DC Field | Value | Language |
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dc.contributor.author | Sati, Satish | - |
dc.contributor.author | Bonev, Boyan | - |
dc.contributor.author | Szabo, Quentin | - |
dc.contributor.author | Jost, Daniel | - |
dc.contributor.author | Bensadoun, Paul | - |
dc.contributor.author | Serra, Francois | - |
dc.contributor.author | Loubiere, Vincent | - |
dc.contributor.author | Papadopoulos, Giorgio Lucio | - |
dc.contributor.author | Rivera-Mulia, Juan-Carlos | - |
dc.contributor.author | Frisch, Lauriane | - |
dc.contributor.author | Bouret, Pauline | - |
dc.contributor.author | Castillo, David | - |
dc.contributor.author | Gelpí Buchaca, Josep Lluís | - |
dc.contributor.author | Orozco López, Modesto | - |
dc.contributor.author | Vaillant, Cedric | - |
dc.contributor.author | Pellestor, Franck | - |
dc.contributor.author | Bantignies, Frederic | - |
dc.contributor.author | Marti Renom, Marc A. | - |
dc.contributor.author | Gilbert, David M. | - |
dc.contributor.author | Lemaitre, Jean-Marc | - |
dc.contributor.author | Cavalli, Giacomo | - |
dc.date.accessioned | 2020-11-12T15:54:00Z | - |
dc.date.available | 2020-11-12T15:54:00Z | - |
dc.date.issued | 2020-05-07 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172030 | - |
dc.description.abstract | To understand the role of the extensive senescence-associated 3D genome reorganization, we generated genome-wide chromatin interaction maps, epigenome, replication-timing, whole-genome bisulfite sequencing, and gene expression profiles from cells entering replicative senescence (RS) or upon oncogene-induced senescence (OIS). We identify senescence-associated heterochromatin domains (SAHDs). Differential intra- versus inter-SAHD interactions lead to the formation of senescence-associated heterochromatin foci (SAHFs) in OIS but not in RS. This OIS-specific configuration brings active genes located in genomic regions adjacent to SAHDs in close spatial proximity and favors their expression.We also identify DNMT1 as a factor that induces SAHFs by promoting HMGA2 expression. Upon DNMT1 depletion, OIS cells transition to a 3D genome conformation akin to that of cells in replicative senescence. These data show how multi-omics and imaging can identify critical features of RS and OIS and discover determinants of acute senescence and SAHF formation. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cell Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.molcel.2020.03.007 | - |
dc.relation.ispartof | Molecular Cell, 2020, vol. 78, num. 3, p. 522-538 | - |
dc.relation.uri | https://doi.org/10.1016/j.molcel.2020.03.007 | - |
dc.rights | cc-by-nc-nd (c) Elsevier, 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Oncogènesi | - |
dc.subject.classification | Cromatina | - |
dc.subject.classification | Epigenètica | - |
dc.subject.other | Carcinogenesis | - |
dc.subject.other | Chromatin | - |
dc.subject.other | Epigenetics | - |
dc.title | 4D Genome rewiring during oncogene-induced and replicative senescende | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 702488 | - |
dc.date.updated | 2020-11-12T15:54:00Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/232947/EU//FLYINGPOLYCOMB | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/609989/EU//4D-GENOME | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/676556/EU//MuG | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/788972/EU//3DEpi | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32220303 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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702488.pdf | 11.06 MB | Adobe PDF | View/Open |
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