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Title: Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Author: Zamora-Ros, Raul
Luján Barroso, Leila
Achaintre, David
Franceschi, Silvia
Kyrø, Cecilie
Overvad, Kim
Tjønneland, Anne
Truong, Therese
Lecuyer, Lucie
Boutron-Ruault, Marie-Christine
Katzke, Verena
Johnson, Theron S.
Schulze, Matthias B.
Trichopoulou, Antonia
Peppa, Eleni
Vecchia, Carlo La
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Skeie, Guri
Quirós, J. Ramón
Rodríguez Barranco, Miguel
Amiano, Pilar
Chirlaque, María Dolores
Ardanaz, Eva
Almquist, Martin
Hennings, Joakim
Vermeulen, Roel
Wareham, Nicholas J.
Tong, Tammy Y. N.
Aune, Dagfinn
Byrnes, Graham
Weiderpass, Elisabete
Scalbert, Augustin
Rinaldi, Sabina
Agudo, Antonio
Keywords: Càncer
Issue Date: 6-Oct-2020
Publisher: Oxford University Press (OUP)
Abstract: Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.
Note: Versió postprint del document publicat a:
It is part of: The American Journal of Clinical Nutrition, 2020
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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