Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172185
Title: Shared genetic background between children and adults with attention deficit/hyperactivity disorder
Author: Rovira, Paula
Demontis, Ditte
Sánchez Mora, Cristina Pilar
Zayats, Tetyana
Klein, Marieke
Roth Mota, Nina
Weber, Heike
Garcia-Martínez, Iris
Pagerols, Mireia
Vilar, Laura
Arribas, Lorena
Richarte, Vanesa
Corrales, Montserrat
Fadeuilhe, Christian
Bosch, Rosa
Español, Gemma
Grevet, Eugenio Horacio
Halmøy, Anne
Hutz, Mara
Knappskog, Per M.
Lundervold, Aastri J.
Rovaris, Diego Luiz
Santos da Silva, Bruna
Sprooten, Emma
ADHD Working Group of the Psychiatric Genomics Consortium
Arias Vasquez, Alejandro
Sonuga-Barke, Edmund
Asherson, Philip
Bau, Claiton Henrique Dotto
Buitelaar, Jan K.
Cormand Rifà, Bru
Faraone, Stephen V.
Haavik, Jan
Johansson, Stefan E.
Kuntsi, Jonna
Larsson, Henrik
Lesch, Klaus-Peter
Reif, Andreas
Keywords: Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Trastorns per dèficit d'atenció amb hiperactivitat en els adults
Attention deficit disorder with hyperactivity in children
Attention deficit disorder with hyperactivity in adults
Issue Date: 12-Apr-2020
Publisher: Nature Publishing Group
Abstract: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41386-020-0664-5
It is part of: Neuropsychopharmacology, 2020, vol. 45, p. 1617-1626
URI: http://hdl.handle.net/2445/172185
Related resource: https://doi.org/10.1038/s41386-020-0664-5
ISSN: 0893-133X
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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