Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172224
Title: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Author: Ji, Xuemei
Bossé, Yohan
Landi, Maria Teresa
Gui, Jiang
Xiao, Xiangjun
Qian, David
Joubert, Philippe
Lamontagne, Maxime
Li, Yafang
Gorlov, Ivan
Biasi, Mariella de
Su, Li
Davies, Michael P. A.
Zhang, Ruyang
Haiman, Christopher
Trichopoulou, Antonia
Brhane, Yonathan
Leighl, Natasha
Johansen, Jakob S.
Mellemgaard, Anders
Fernández Somoano, Ana
Doherty, Jennifer
Fernández Tardón, Guillermo
van der Heijden, Erik H. F. M.
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Marcus, Michael W.
Manz, Judith
Brunnström, Hans
Tumino, Rosario
Manjer, Jonas
Tsao, Ming-Sound
Melander, Olle
Muller, David C.
Overvad, Kim
Goodman, Gary E.
Mukeriya, Anush
Cox, Angela
Taylor, Fiona
Woll, Penella
Brüske, Irene
Muley, Thomas R.
Orlowski, Tadeusz M.
Risch, Angela
Arnold, Susanne M.
Rosenberger, Albert
Grankvist, Kjell
Johansson, Mikael
Shepherd, Frances
Haura, Eric B.
Duell, Eric J.
Bolca, Ciprian
Ognjanovic, Simona
Nickle, David C.
Holcatova, Ivana
Janout, Vladimir
Kontic, Milica
Lissowska, Jolanta
Scelo, Ghislaine
Swiatkowska, Beata
Johansson, M
Zaridze, David
Bakke, Per
Skaug, Vidar
Zienolddiny, Shanbeh
Butler, Lesley M.
Byun, Jinyoung
Koh, Woon-Puay
Obeidat, Ma'en
Gao, Yu-Tang
Houlston, Richard
McLaughlin, John R.
Stevens, Victoria
Timens, Wim
Hung, Rayjean J.
Zhu, Bin
Gu, Fangyi
Johansson, Mattias
Song, Lei
Soler Artigas, María
Tobin, Martin D.
Wain, Louise V.
Kamal, Ahsan
Zhu, Dakai
Tardón, Adonina
Tyndale, Rachel F.
Wei, Wei-Qi
Chanock, Stephen J.
Brennan, Paul
Wu, Xifeng
Chen, Chu
McKay, James D.
Liu, Geoffrey
Zong, Xuchen
Carreras-Torres, Robert
Christiani, David C.
Caporaso, Neil E.
Bojesen, Stig E.
Schabath, Matthew B.
Marchand, Loïc Le
Rennert, Gad
Ye, Yuanqing
Albanes, Demetrius
Bickeböller, Heike
Aldrich, Melinda C.
Bush, William S.
Teare, M. Dawn
Field, John K.
Saliba, Walid
Kiemeney, Lambertus A.
Philip, Lazarus
Haugen, Aage
Lam, Stephen
Andrew, Angeline S.
Wilkens, Lynne
Shen, Hongbing
Diao, Nancy
Hong, Yun-Chul
Yuan, Jian-Min
Bertazzi, Pier Alberto
Pesatori, Angela C.
Keywords: Càncer de pulmó
Factors de risc en les malalties
Lung cancer
Risk factors in diseases
Issue Date: 13-Aug-2018
Publisher: Nature Publishing Group
Abstract: Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-05074-y
It is part of: Nature Communications, 2018, vol. 9
URI: http://hdl.handle.net/2445/172224
Related resource: https://doi.org/10.1038/s41467-018-05074-y
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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