Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172224
Title: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Author: Ji, Xuemei
Bossé, Yohan
Landi, Maria Teresa
Gui, Jiang
Xiao, Xiangjun
Qian, David
Joubert, Philippe
Lamontagne, Maxime
Li, Yafang
Gorlov, Ivan
Biasi, Mariella de
Davies, Michael P. A.
Ognjanovic, S
Marcus, Michael W.
Brunnström, Hans
Tumino, Rosario
Manjer, Jonas
Melander, Olle
Muller, David C.
Overvad, Kim
Doherty, Jennifer
Tsao, Ming-Sound
Goodman, Gary E.
Orlowski, Tm
Cox, Angela
Taylor, Fiona
Woll, Penella
Brüske, Irene
Manz, Judith
Mukeria, Anush
Muley, Thomas
Risch, Angela
Arnold, Susanne M.
Rosenberger, Albert
Grankvist, Kjell
Johansson, Mikael
Shepherd, Frances
Haura, Eric B.
Bolca, Ciprian
Ognjanovic, Simona
Holcatova, Ivana
Janout, Vladimir
Kontic, Milica
Lissowska, Jolanta
Orlowski, Tadeusz M.
Nickle, David C.
Scelo, Ghislaine
Swiatkowska, Beata
Zaridze, David
Bakke, Per
Skaug, Vidar
Zienolddiny, Shanbeh
Duell, Eric J.
Johansson, M
Butler, Lesley M.
Koh, Woon-Puay
Obeidat, Ma’en
Gao, Yu-Tang
Houlston, Richard
McLaughlin, John
Stevens, Victoria
Timens, Wim
Zhu, Bin
Gu, Fangyi
Song, Lei
Soler Artigas, María
Tobin, Martin D.
Wain, Louise V.
Byun, Jinyoung
Johansson, Mattias
Kamal, Ahsan
Zhu, Dakai
Tyndale, Rachel F.
Wei, Wei-Qi
Chanock, Stephen
Brennan, Paul
Hung, Rayjean J.
Tardón, Adonina
Wu, Xifeng
McKay, James
Liu, Geoffrey
Zong, Xuchen
Carreras-Torres, Robert
Christiani, David C.
Caporaso, Neil
Bojesen, Stig E.
Marchand, Loic Le
Rennert, Gad
Albanes, Demetrius
Bickeböller, Heike
Aldrich, Melinda C.
Bush, William S.
Chen, Chu
Ye, Yuanqing
Teare, M. Dawn
Field, John K.
Kiemeney, Lambertus A.
Philip, Lazarus
Haugen, Aage
Lam, Stephen
Schabath, Matthew B.
Saliba, Walid
Andrew, Angeline S.
Shen, Hongbing
Diao, Nancy
Hong, Yun-Chul
Yuan, Jian-Min
Bertazzi, Pier Alberto
Pesatori, Angela C.
Su, Li
Zhang, Ruyang
Haiman, Christopher
Brhane, Yonathan
Leighl, Natasha
Johansen, Jakob S.
Mellemgaard, Anders
Wilkens, Lynne
Trichopoulou, Antonia
Fernández Somoano, Ana
Fernández Tardón, Guillermo
van der Heijden, Erik H. F. M.
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Keywords: Càncer de pulmó
Factors de risc en les malalties
Lung cancer
Risk factors in diseases
Issue Date: 13-Aug-2018
Publisher: Nature Publishing Group
Abstract: Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-05074-y
It is part of: Nature Communications, 2018, vol. 9
URI: http://hdl.handle.net/2445/172224
Related resource: https://doi.org/10.1038/s41467-018-05074-y
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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