Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/172232
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thomas, Hala Elnakat | - |
dc.contributor.author | Zhang, Yu | - |
dc.contributor.author | Stefely, Jonathan A. | - |
dc.contributor.author | Veiga, Sonia R. | - |
dc.contributor.author | Thomas, George | - |
dc.contributor.author | Kozma, Sara C. | - |
dc.contributor.author | Mercer, Carol A. | - |
dc.date.accessioned | 2020-11-20T11:06:32Z | - |
dc.date.available | 2020-11-20T11:06:32Z | - |
dc.date.issued | 2018-08-28 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172232 | - |
dc.description.abstract | Cells adapt to nutrient and energy deprivation by inducing autophagy, which is regulated by the mammalian target of rapamycin (mTOR) and AMP-activated protein kinases (AMPKs). We found that cell metabolism significantly influences the ability to induce autophagy, with mitochondrial complex I function being an important factor in the initiation, amplitude, and duration of the response. We show that phenformin or genetic defects in complex I suppressed autophagy induced by mTOR inhibitors, whereas autophagy was enhanced by strategies that increased mitochondrial metabolism. We report that mTOR inhibitors significantly increased select phospholipids and mitochondrial-associated membranes (MAMs) in a complex I-dependent manner. We attribute the complex I autophagy defect to the inability to increase MAMs, limiting phosphatidylserine decarboxylase (PISD) activity and mitochondrial phosphatidylethanolamine (mtPE), which support autophagy. Our data reveal the dynamic and metabolic regulation of autophagy. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cell Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.celrep.2018.07.101 | - |
dc.relation.ispartof | Cell Reports, 2018, vol. 24, num. 9, p. 2404–2417 | - |
dc.relation.uri | https://doi.org/10.1016/j.celrep.2018.07.101 | - |
dc.rights | cc by nc-nd (c) Thomas et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Autofàgia | - |
dc.subject.classification | Mitocondris | - |
dc.subject.other | Autophagy | - |
dc.subject.other | Mitochondria | - |
dc.title | Mitochondrial Complex I Activity Is Required for Maximal Autophagy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-11-11T17:42:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30157433 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Thomas.pdf | 2.25 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License