Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172395
Title: An observational pilot study evaluating the utility of minimally invasive tissue sampling to determine the cause of stillbirths in South African women
Author: Madhi, Shabir A.
Pathirana, Jayani
Baillie, Vicky
Cutland, Clare
Adam, Yasmin
Izu, Alane
Bassat Orellana, Quique
Blau, Dianna M.
Breiman, Robert F.
Hale, Martin
Johnstone, Siobhan
Martines, Roosecelis B.
Mathunjwa, Azwifarwi
Nzenze, Susan
Ordi i Majà, Jaume
Raghunathan, Pratima L.
Ritter, Jana M.
Solomon, Fatima
Wadula, Jeannette
Zaki, Sherif R.
Chawana, Richard
Keywords: Mort del fetus
Hipertensió en l'embaràs
Fetal death
Hypertension in pregnancy
Issue Date: 9-Oct-2019
Publisher: Oxford University Press
Abstract: BACKGROUND: Despite approximately 2.6 million stillbirths occurring annually, there is a paucity of systematic biological investigation and consequently knowledge on the causes of these deaths in low- and middle-income countries (LMICs). We investigated the utility of minimally invasive tissue sampling (MITS), placental examination, and clinical history, in attributing the causes of stillbirth in a South African LMIC setting. METHODS: This prospective, observational pilot study undertook sampling of brain, lung, and liver tissue using core biopsy needles, blood and cerebrospinal fluid collection, and placental examination. Testing included microbial culture and/or molecular testing and tissue histological examination. The cause of death was determined for each case by an international panel of medical specialists and categorized using the World Health Organization's International Classification of Diseases, Tenth Revision application to perinatal deaths. RESULTS: A cause of stillbirth was identifiable for 117 of 129 (90.7%) stillbirths, including an underlying maternal cause in 63.4% (n = 83) and an immediate fetal cause in 79.1% (n = 102) of cases. The leading underlying causes of stillbirth were maternal hypertensive disorders (16.3%), placental separation and hemorrhage (14.0%), and chorioamnionitis (10.9%). The leading immediate causes of fetal death were antepartum hypoxia (35.7%) and fetal infection (37.2%), including due to Escherichia coli (16.3%), Enterococcus species (3.9%), and group B Streptococcus (3.1%). CONCLUSIONS: In this pilot, proof-of-concept study, focused investigation of stillbirth provided granular detail on the causes thereof in an LMIC setting, including provisionally highlighting the largely underrecognized role of fetal sepsis as a dominant cause.
Note: Reproducció del document publicat a: https://doi.org/10.1093/cid/ciz573
It is part of: Clinical Infectious Diseases, 2019, vol. 69, num. 4, p. 342-350
URI: http://hdl.handle.net/2445/172395
Related resource: https://doi.org/10.1093/cid/ciz573
ISSN: 1058-4838
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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