Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172456
Title: Effectiveness of physically ablative (electrosurgery excision, infrared coagulation) and pharmacological treatments (imiquimod) for anal canal condylomata in HIV-infected men
Author: Vela, Sandra
Videla, Sebas
Ornelas, Arelly
Revollo, Boris
Clotet i Sala, Bonaventura
Sirera, Guillem
Piñol, Marta
García Cuyás, Francesc
Keywords: Infeccions per VIH
Antiretrovirals
HIV infections
Antiretroviral agents
Issue Date: 1-Aug-2018
Publisher: Public Library of Science (PLoS)
Abstract: Background: There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. Aim: To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice. Methods: Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed. Results: Between January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2-15%) with electrosurgery excision, 11% (3/27, 95%CI: 4-28%) with infrared coagulation and 11% (1/9, 95%CI: 2-44%) with imiquimod treatment. No predictive factors were associated with recurrence. Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection. Conclusion: Recurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0199033
It is part of: PLoS One, 2018, vol. 13, num. 8, p. e0199033
URI: http://hdl.handle.net/2445/172456
Related resource: https://doi.org/10.1371/journal.pone.0199033
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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