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DC Field | Value | Language |
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dc.contributor.author | Vela, Sandra | - |
dc.contributor.author | Videla, Sebas | - |
dc.contributor.author | Ornelas Vargas, Arelly | - |
dc.contributor.author | Revollo, Boris | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Sirera, Guillem | - |
dc.contributor.author | Piñol, Marta | - |
dc.contributor.author | García Cuyás, Francesc | - |
dc.date.accessioned | 2020-12-01T13:16:32Z | - |
dc.date.available | 2020-12-01T13:16:32Z | - |
dc.date.issued | 2018-08-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172456 | - |
dc.description.abstract | Background: There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. Aim: To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice. Methods: Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed. Results: Between January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2-15%) with electrosurgery excision, 11% (3/27, 95%CI: 4-28%) with infrared coagulation and 11% (1/9, 95%CI: 2-44%) with imiquimod treatment. No predictive factors were associated with recurrence. Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection. Conclusion: Recurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0199033 | - |
dc.relation.ispartof | PLoS One, 2018, vol. 13, num. 8, p. e0199033 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0199033 | - |
dc.rights | cc-by (c) Vela, Sandra et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Antiretroviral agents | - |
dc.title | Effectiveness of physically ablative (electrosurgery excision, infrared coagulation) and pharmacological treatments (imiquimod) for anal canal condylomata in HIV-infected men | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 697974 | - |
dc.date.updated | 2020-12-01T13:16:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30067738 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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697974.pdf | 1.43 MB | Adobe PDF | View/Open |
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