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http://hdl.handle.net/2445/172457
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DC Field | Value | Language |
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dc.contributor.author | Esteve i Comas, Maria | - |
dc.contributor.author | Rosinach, Mercè | - |
dc.contributor.author | Llordés, Montserrat | - |
dc.contributor.author | Calpe, Judit | - |
dc.contributor.author | Montserrat, Glòria | - |
dc.contributor.author | Pujals, Mar | - |
dc.contributor.author | Cela, Abel | - |
dc.contributor.author | Carrasco García, Anna | - |
dc.contributor.author | Ibarra, Montserrat | - |
dc.contributor.author | Ruiz Ramirez, Pablo | - |
dc.contributor.author | Tristán, Eva | - |
dc.contributor.author | Arau, Beatriz | - |
dc.contributor.author | Ferrer, Carme | - |
dc.contributor.author | Mariné, Meritxell | - |
dc.contributor.author | Ribes Puig, Josepa | - |
dc.contributor.author | Fernández Bañares, Fernando | - |
dc.contributor.author | Primary Care Coeliac Disease Study Group | - |
dc.date.accessioned | 2020-12-01T13:45:19Z | - |
dc.date.available | 2020-12-01T13:45:19Z | - |
dc.date.issued | 2018-07-01 | - |
dc.identifier.issn | 2050-6406 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172457 | - |
dc.description.abstract | Background: An on-site, rapid, fingertip, whole-blood point-of-care test (POCT) is attractive for active case-finding of coeliac disease (CD) in primary care because of its simplicity. Aim: The aim of this article is to assess the usefulness and cost-effectiveness of adult case-finding using a POCT based on deamidated gliadin peptide antibodies (IgA/IgG-DGP) in primary care for CD diagnosis. Methods: A case-finding study for CD was conducted by using an easy-to-use, on-site, whole-blood for IgA/IgG-DGP-based fingertip POCT compared with tTG2 in 350 individuals. Sample size was calculated based on 0.28% prevalence in the reference population. Duodenal biopsies for histology, intraepithelial lymphocytes and in situ deposition of tTG2 were obtained if tTG2 and/or POCT were positive. Accuracy and cost-effectiveness of strategies using serology or POCT were calculated. Results: Prevalence of CD was 1.14% (95% CI, 0.3-3.4), almost double what was previously observed. Four patients were diagnosed with CD. tTG2 was positive in three (0.85%) and POCT in 29 (8.2%). Sensitivity of POCT for CD was 100%, specificity 93%, PPV 14%, and NPV 100%. POCT followed by duodenal biopsy was the most cost-effective approach in our setting (standard diagnosis: E13,033/case; POCT þ duodenal biopsy: E7360/case). Conclusions: A negative POCT allows ruling out CD in primary care, making it suitable for case-finding. POCT strategy was the most cost effective. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | SAGE Publications | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1177/2050640618761700 | - |
dc.relation.ispartof | United European Gastroenterology Journal, 2018, vol. 6, num. 6, p. 855-865 | - |
dc.relation.uri | https://doi.org/10.1177/2050640618761700 | - |
dc.rights | cc by-nc (c) Esteve i Comas, Maria et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Malaltia celíaca | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Celiac disease | - |
dc.subject.other | Diagnosis | - |
dc.title | Case-finding in primary care for coeliac disease: Accuracy and cost-effectiveness of a rapid point-of-care test | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 684837 | - |
dc.date.updated | 2020-12-01T13:45:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30023063 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Medicina) Articles publicats en revistes (Ciències Clíniques) |
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684837.pdf | 510.73 kB | Adobe PDF | View/Open |
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