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Title: Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer
Author: Neumeyer, Sonja
Banbury, Barbara L.
Arndt, Volker
Berndt, Sonja I.
Bézieau, Stéphane
Bien, Stephanie A.
Buchanan, Daniel D.
Butterbach, Katja
Caan, Bette J.
Campbell, Peter T.
Casey, Graham
Chan, Andrew T.
Chanock, Stephen J.
Dai, James Y.
Gallinger, Steven
Giovannucci, Edward L.
Giles, Graham G.
Grady, William M.
Hampe, Jochen
Hoffmeister, Michael
Hopper, John L.
Hsu, Li
Jenkins, Mark A.
Joshi, Amit
Larsson, Susanna C.
Marchand, Loic Le
Lindblom, Annika
Moreno Aguado, Víctor
Lemire, Mathieu
Li, Li
Lin, Yi
Offit, Kenneth
Newcomb, Polly A.
Pharaoh, Paul D.
Potter, John D.
Qi, Lihong
Rennert, Gad
Schafmayer, Clemens
Schoen, Robert E.
Slattery, Martha L.
Song, Mingyang
Ulrich, Cornelia M.
Win, Aung K.
White, Emily
Wolk, Alicja
Woods, Michael O.
Wu, Anna H.
Gruber, Stephen B.
Brenner, Hermann
Peters, Ulrike
Chang-Claude, Jenny
Keywords: Càncer colorectal
Colorectal cancer
Issue Date: 1-Jun-2018
Publisher: Cancer Research UK
Abstract: BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent. METHODS: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index. RESULTS: Genetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results. CONCLUSIONS: Our study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.
Note: Reproducció del document publicat a:
It is part of: British Journal of Cancer, 2018, vol. 118, num. 12, p. 1639-1647
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ISSN: 0007-0920
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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