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http://hdl.handle.net/2445/172469
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DC Field | Value | Language |
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dc.contributor.author | Guo, Fukun | - |
dc.contributor.author | Zhang, Shuangmin | - |
dc.contributor.author | Grogg, Matthew | - |
dc.contributor.author | Cancelas, Jose A. | - |
dc.contributor.author | Varney, Melinda E. | - |
dc.contributor.author | Starczynowski, Daniel T. | - |
dc.contributor.author | Du, Wei | - |
dc.contributor.author | Yang, Jun-Qi | - |
dc.contributor.author | Liu, Wei | - |
dc.contributor.author | Thomas, George | - |
dc.contributor.author | Kozma, Sara | - |
dc.contributor.author | Pang, Qishen | - |
dc.contributor.author | Zheng, Yi | - |
dc.date.accessioned | 2020-11-30T17:06:04Z | - |
dc.date.available | 2020-11-30T17:06:04Z | - |
dc.date.issued | 2013-09-01 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172469 | - |
dc.description.abstract | mTOR integrates signals from nutrients and growth factors to control protein synthesis, cell growth, and survival. Although mTOR has been established as a therapeutic target in hematologic malignancies, its physiological role in regulating hematopoiesis remains unclear. Here we show that conditional gene targeting of mTOR causes bone marrow failure and defects in multi-lineage hematopoiesis including myelopoiesis, erythropoiesis, thrombopoiesis, and lymphopoiesis. mTOR deficiency results in loss of quiescence of hematopoietic stem cells, leading to a transient increase but long-term exhaustion and defective engraftment of hematopoietic stem cells in lethally irradiated recipient mice. Furthermore, ablation of mTOR causes increased apoptosis in lineage-committed blood cells but not hematopoietic stem cells, indicating a differentiation stage-specific function. These results demonstrate that mTOR is essential for hematopoietic stem cell engraftment and multi-lineage hematopoiesis. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2012.080424 | - |
dc.relation.ispartof | Haematologica, 2013, vol. 98, num. 9, p. 1353-1358 | - |
dc.relation.uri | https://doi.org/10.3324/haematol.2012.080424 | - |
dc.rights | (c) Ferrata Storti Foundation, 2013 | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Hematopoesi | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Genètica | - |
dc.subject.other | Hematopoiesis | - |
dc.subject.other | Physiology | - |
dc.subject.other | Genetics | - |
dc.title | Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 672958 | - |
dc.date.updated | 2020-11-30T17:06:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23716557 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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672958.pdf | 264.01 kB | Adobe PDF | View/Open |
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