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http://hdl.handle.net/2445/172685
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DC Field | Value | Language |
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dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.date.accessioned | 2020-12-11T16:23:19Z | - |
dc.date.available | 2020-12-11T16:23:19Z | - |
dc.date.issued | 2020-03-15 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172685 | - |
dc.description.abstract | Adenosine is a purine nucleoside present in all human cells where it plays many different physiological roles: From being a building block for nucleic acids to a key constituent of the biological energy currency ATP. Indeed, more than 90 years ago, Drury and Szent-Györgyi reported that adenosine produces profound hypotension and bradycardia, and until the present time, the list of physiological effects of adenosine has expanded considerably. In addition, adenosine is a well-known neuromodulator in the brain and has effects on other tissues, thus exerting its physiological actions through four different subtypes of G protein-coupled adenosine receptors (i.e., A1R, A2AR, A2BR and A3R) which, as expected, are expressed in a large variety of cells throughout the body. Consequently, ARs are potential therapeutic targets in a variety of pathophysiological conditions, including cancer, cardiovascular diseases, neurological disorders, and inflammatory and autoimmune diseases. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ijms21061997 | - |
dc.relation.ispartof | International Journal of Molecular Sciences, 2020, vol. 21, num. 6, p. 1997 | - |
dc.relation.uri | https://doi.org/10.3390/ijms21061997 | - |
dc.rights | cc-by (c) Ciruela Alférez, Francisco, 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Adenosina | - |
dc.subject.classification | Proteïnes G | - |
dc.subject.classification | Molècules | - |
dc.subject.other | Adenosine | - |
dc.subject.other | G Proteins | - |
dc.subject.other | Molecules | - |
dc.title | Special issue: G protein-coupled adenosine receptors: molecular aspects and beyond | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 700498 | - |
dc.date.updated | 2020-12-11T16:23:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32183407 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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File | Description | Size | Format | |
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700498.pdf | 193.06 kB | Adobe PDF | View/Open |
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