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Title: Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas
Author: Gallardo, Fernando
Esteller, Manel
Pujol, Ramon M.
Costa, Carlota
Estrach Panella, Ma. Teresa (María Teresa)
Servitje Bedate, Octavio
Keywords: Genètica
Cèl·lules T
T cells
Issue Date: 1-Nov-2004
Publisher: Ferrata Storti Foundation
Abstract: p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.
Note: Reproducció del document publicat a:
It is part of: Haematologica, 2004, vol. 89, num. 11, p. 1401-1403
ISSN: 0390-6078
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Medicina)

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