Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/172750
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pascual-González, Yuliana | - |
dc.contributor.author | López Sánchez, Marta | - |
dc.contributor.author | Dorca i Sargatal, Jordi | - |
dc.contributor.author | Santos Pérez, Salud | - |
dc.date.accessioned | 2020-12-15T18:15:14Z | - |
dc.date.available | 2020-12-15T18:15:14Z | - |
dc.date.issued | 2018-01-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172750 | - |
dc.description.abstract | COPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-effective inflammatory marker derived from routine complete blood count. We performed a systematic literature review using the PRISMA statement. Twenty-two articles were included, recruiting 7,601 COPD patients and 784 healthy controls. Compared with controls, COPD patients had significantly higher NLR values. We found a significant correlation between the NLR and clinical/functional parameters (FEV1, mMRC, and BODE index) in COPD patients. Elevation of the NLR is associated with the diagnosis of acute exacerbation of COPD (pooled data propose a cut-off value of 3.34 with a median sensitivity, specificity, and area under the curve of 80%, 86%, and 0.86, respectively). Additionally, increased NLR is also associated with the diagnosis of a bacterial infection in exacerbated patients, with a cut-off value of 7.30, although with a low sensitivity and specificity. The NLR is an independent predictor of in-hospital and late mortality after exacerbation. In conclusion, the NLR could be a useful marker in COPD patients; however, further studies are needed to better identify the clinical value of the NLR. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Dove Medical Press Ltd. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2147/COPD.S178068 | - |
dc.relation.ispartof | International Journal of Chronic Obstructive Pulmonary Disease, 2018, vol. 13, p. 3651-3662 | - |
dc.relation.uri | https://doi.org/10.2147/COPD.S178068 | - |
dc.rights | cc by-nc (c) Pascual-González et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Mortality | - |
dc.title | Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 684369 | - |
dc.date.updated | 2020-12-04T12:34:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30464448 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Pascual-GonzalezY.pdf | 787.45 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License