Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172750
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dc.contributor.authorPascual-González, Yuliana-
dc.contributor.authorLópez Sánchez, Marta-
dc.contributor.authorDorca i Sargatal, Jordi-
dc.contributor.authorSantos Pérez, Salud-
dc.date.accessioned2020-12-15T18:15:14Z-
dc.date.available2020-12-15T18:15:14Z-
dc.date.issued2018-01-01-
dc.identifier.urihttp://hdl.handle.net/2445/172750-
dc.description.abstractCOPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-effective inflammatory marker derived from routine complete blood count. We performed a systematic literature review using the PRISMA statement. Twenty-two articles were included, recruiting 7,601 COPD patients and 784 healthy controls. Compared with controls, COPD patients had significantly higher NLR values. We found a significant correlation between the NLR and clinical/functional parameters (FEV1, mMRC, and BODE index) in COPD patients. Elevation of the NLR is associated with the diagnosis of acute exacerbation of COPD (pooled data propose a cut-off value of 3.34 with a median sensitivity, specificity, and area under the curve of 80%, 86%, and 0.86, respectively). Additionally, increased NLR is also associated with the diagnosis of a bacterial infection in exacerbated patients, with a cut-off value of 7.30, although with a low sensitivity and specificity. The NLR is an independent predictor of in-hospital and late mortality after exacerbation. In conclusion, the NLR could be a useful marker in COPD patients; however, further studies are needed to better identify the clinical value of the NLR.-
dc.format.extent12 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherDove Medical Press Ltd.-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.2147/COPD.S178068-
dc.relation.ispartofInternational Journal of Chronic Obstructive Pulmonary Disease, 2018, vol. 13, p. 3651-3662-
dc.relation.urihttps://doi.org/10.2147/COPD.S178068-
dc.rightscc by-nc (c) Pascual-González et al., 2018-
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/-
dc.sourceArticles publicats en revistes (Ciències Clíniques)-
dc.subject.classificationMalalties pulmonars obstructives cròniques-
dc.subject.classificationMortalitat-
dc.subject.otherChronic obstructive pulmonary diseases-
dc.subject.otherMortality-
dc.titleDefining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec684369-
dc.date.updated2020-12-04T12:34:50Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid30464448-
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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