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Title: Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of latrogenesis in Older Subjects receiving Parenteral Nutrition)
Author: Mateu de Antonio, Javier
Berlana, David
Pons Busom, Montserrat
Badia Tahull, Maria Bella
Miana Mena, María Teresa
Martínez Caste, Beatriz
Sunyer Esquerrà, Neus
Sanmartin Suñer, Mónica
González Valdivieso, Juan
Leiva Badosa, Elisabet
Martínez Bernabé, Eva
Murgadella Sancho, Anna
Mirerachs Aranda, Nuria
Vila Bundó, Anna
Fernández Morató, Jordi
Vitales Farrero, María Teresa
Keywords: Hiperglucèmia
Malalties de les persones grans
Older people diseases
Issue Date: 1-Mar-2018
Publisher: Arán Ediciones S.L.
Abstract: Objective: this study assessed the incidence of hyperglycemia, hypertriglyceridemia, and liver function test (LFT) alterations among patients older and younger than 65 years receiving parenteral nutrition (PN). A secondary objective was to compare the incidence of any of these three events. Material and methods: inclusion criteria were non-critically ill adult inpatients receiving PN for 7 days in 15 hospitals in Spain. Exclusion criteria were hyperglycemia, hypertriglyceridemia, LFT alterations, sepsis, shock, pancreatic/hepatobiliary surgery, renal failure, diabetes mellitus (DM) type 1, insulin-treated DM type 2, acute DM complications, or obesity prior to PN. Patients were classified into groups YOUNG (aged 35-64) and OLD (aged 65-95). Results: this study recruited 200 patients. Group YOUNG included 63 (31.5%) patients and OLD, 137 (68.5%). Hyperglycemia appeared in 37 (18.5%) patients, eight (12.7%) in group YOUNG and 29 (21.2%) in group OLD (p = 0.174). Hypertriglyceridemia appeared in only one (0.7%) patient. LFT alterations appeared in 141 (70.5%) patients, 44 (69.8%) in group YOUNG and 97 (70.8%) in group OLD (p = 1.000). The model for hyperglycemia included DM type 2, previous surgical procedure, and use of hyperglycemia-inducing medications. The model for LFT alteration included previous surgical procedure, amount of lipids and amino acids, medications causing LFT alterations and a trend for age group. The model for any event included surgical procedure, DM type 2, and medications causing alterations. Conclusion: patients of 65 years receiving PN had similar incidences of hyperglycemia, hypertriglyceridemia, and LFT alterations as younger patients. Additionally, older patients had trends toward lower LET alterations.
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It is part of: Nutricion Hospitalaria, 2018-03-01, vol. 35, num. 2, p. 252-258
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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