Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/172844
Title: | Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia |
Author: | Stein, Heike Barbosa, João Moura Rosa Justicia, Mireia Prades, Laia Morató, Alba Galan-Gadea, Adria Ariño Rodríguez, Helena Martínez Hernández, Eugenia Castro Fornieles, Josefina Dalmau Obrador, Josep Compte Braquets, Albert |
Keywords: | Memòria Esquizofrènia Encefalitis Memory Schizophrenia Encephalitis |
Issue Date: | 25-Aug-2020 |
Publisher: | Nature Publishing Group |
Abstract: | A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account of two symptomatologically related diseases, both linked to hypofunctional NMDARs: schizophrenia and autoimmune anti-NMDAR encephalitis. We first quantified shared working memory alterations in a delayed-response task. In both patient groups, we report a markedly reduced influence of previous stimuli on working memory contents, despite preserved memory precision. We then simulated this finding with NMDAR-dependent synaptic alterations in a microcircuit model of prefrontal cortex. Changes in cortical excitation destabilized within-trial memory maintenance and could not account for disrupted serial dependence in working memory. Rather, a quantitative fit between data and simulations supports alterations of an NMDAR-dependent memory mechanism operating on longer timescales, such as short-term potentiation. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-18033-3 |
It is part of: | Nature Communications, 2020, vol. 11, num. 1, p. 4250 |
URI: | http://hdl.handle.net/2445/172844 |
Related resource: | https://doi.org/10.1038/s41467-020-18033-3 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
705301.pdf | 1.42 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License