Please use this identifier to cite or link to this item:
Title: Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice
Author: Aso Pérez, Ester
Serrano, Antonio L.
Muñoz Cánoves, Pura, 1962-
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Ratolins (Animals de laboratori)
Malaltia d'Alzheimer
Mice (Laboratory animals)
Alzheimer's disease
Issue Date: 21-Apr-2015
Publisher: IOS Press
Abstract: Fibrinogen has emerged as a promising therapeutic target against Alzheimer's disease because of its dual role in altered vascular function and amyloid-β aggregation. Here we provide evidence regarding cognitive improvement and reduction of brain parenchyma amyloid-β deposition in AβPP/PS1 mice after treatment for one month with the fibrinogen-blocking peptide Fibγ377-395. No alteration in glial response or other neuroinflammatory markers was observed in the cortex of treated animals. Considering these results and the fact that Fibγ377-395 does not affect coagulation function, this peptide could be considered as a promising and safe candidate for chronic treatment of Alzheimer's disease.
Note: Reproducció del document publicat a:
It is part of: Journal of Alzheimer's Disease, 2015, vol. 47, num. 2, p. 403-412
Related resource:
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

Files in This Item:
File Description SizeFormat 
697762.pdf517.43 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.