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http://hdl.handle.net/2445/172893
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DC Field | Value | Language |
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dc.contributor.author | Aso Pérez, Ester | - |
dc.contributor.author | Serrano, Antonio L. | - |
dc.contributor.author | Muñoz Cánoves, Pura, 1962- | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.date.accessioned | 2020-12-21T14:07:49Z | - |
dc.date.available | 2020-12-21T14:07:49Z | - |
dc.date.issued | 2015-04-21 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172893 | - |
dc.description.abstract | Fibrinogen has emerged as a promising therapeutic target against Alzheimer's disease because of its dual role in altered vascular function and amyloid-β aggregation. Here we provide evidence regarding cognitive improvement and reduction of brain parenchyma amyloid-β deposition in AβPP/PS1 mice after treatment for one month with the fibrinogen-blocking peptide Fibγ377-395. No alteration in glial response or other neuroinflammatory markers was observed in the cortex of treated animals. Considering these results and the fact that Fibγ377-395 does not affect coagulation function, this peptide could be considered as a promising and safe candidate for chronic treatment of Alzheimer's disease. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IOS Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3233/JAD-142928 | - |
dc.relation.ispartof | Journal of Alzheimer's Disease, 2015, vol. 47, num. 2, p. 403-412 | - |
dc.relation.uri | https://doi.org/10.3233/JAD-142928 | - |
dc.rights | (c) Aso Pérez, Ester et al., 2015 | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Amiloïdosi | - |
dc.subject.classification | Fibrinogen | - |
dc.subject.classification | Inflamació | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Amyloidosis | - |
dc.subject.other | Fibrinogen | - |
dc.subject.other | Inflammation | - |
dc.title | Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 697762 | - |
dc.date.updated | 2020-12-21T14:07:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
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697762.pdf | 517.43 kB | Adobe PDF | View/Open |
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