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Title: Psychological burden of hepatic encephalopathy on patients and caregivers
Author: Fabrellas i Padrès, Núria
Moreira, Rebeca
Carol, Marta
Cervera, Marta
de la Prada, Gloria
Perez, Martina
Vazquez, Elena
Solà Pola, Montserrat
Sancho, Raúl
Juanola, Adrià
Pose, Elisa
Solé Padullés, Cristina
Graupera, Isabel
Solà, Elsa
Kamath, Patrick S.
Ginès i Gibert, Pere
Keywords: Malalties del fetge
Cura dels malalts
Liver diseases
Care of the sick
Issue Date: Apr-2020
Publisher: Wolters Kluwer Health
Abstract: Objectives: Hepatic encephalopathy (HE) is common in advanced cirrhosis and is characterized by marked neuropsychiatric abnormalities. However, despite its severity and effects on brain function, the impact of HE on psychological status of patients has not been adequately assessed. The aim of this study was to evaluate the effect of HE on psychological status of patients and their informal caregivers. Methods: Fifteen patients with cirrhosis and episodic or persistent HE and their corresponding informal caregivers were included. Semistructured interviews were performed in patients and caregivers. Quality of life (QoL) was assessed by the short-form 36 in both patients and caregivers, and the Zarit burden score was measured in caregivers. The analysis of interviews was performed using qualitative methodology. Results: HE causes a major psychological impact on patients with HE. The first episode of HE caused a very significant impact that was reported with deep feelings, mainly of fear, anger, misery, anxiety, and sorrow, which persisted with time. Symptoms causing more psychological impact on patients were impaired ability to walk and speak. All effects were associated with a marked impairment in QoL. The psychological impact was also marked in caregivers who had a major burden, as assessed by the Zarit score. Moreover, QoL, particularly the mental component score, was markedly impaired in caregivers in intensity similar to that of patients. Discussion: HE has a profound psychological impact on patients and their informal caregivers, associated with a marked negative influence on QoL. The psychological effects of HE on patients and caregivers should be evaluated and treated.
Note: Reproducció del document publicat a:
It is part of: Clinical and Translational Gastroenterology, 2020, vol. 11, num. 4, p. e00159
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ISSN: 2155-384X
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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