Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/173022
Title: Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study
Author: Tyrovolas, Stefanos
Panagiotakos, Demosthenes
Georgousopoulou, Ekavi
Chrysohoou, Christina
Tousoulis, Dimitrios
Haro Abad, Josep Maria
Pitsavos, Christos
Keywords: Malalties cardiovasculars
Múscul estriat
Cardiovascular diseases
Striated muscle
Issue Date: 2020
Publisher: BMJ Publishing Group
Abstract: Skeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old. METHODS: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek general population (Caucasians; age ≥18 years; 1514 men). The 10 year study follow-up (2011-2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). The working sample consisted of 1019 participants, 45+ years old (men: n=534; women: n=485). A skeletal muscle mass index (SMI) was created to reflect SMM, using appendicular skeletal muscle mass (ASM) standardised by body mass index (BMI). ASM and SMI were calculated with specific indirect population formulas. RESULTS: The 10 year CVD incidence increased significantly across the baseline SMI tertiles (p<0.001). Baseline SMM showed a significant inverse association with the 10 year CVD incidence (HR 0.06, 95% CI 0.005 to 0.78), even after adjusting for various confounders. Additionally, participants in the highest SMM tertile had 81% (95% CI 0.04 to 0.85) lower risk for a CVD event as compared with those in the lowest SMM tertile. CONCLUSIONS: The presented findings support the importance of SMM evaluation in the prediction of long-term CVD risk among adults 45+ years old without pre-existing CVD. Preservation of SMM may contribute to CVD health.
Note: Reproducció del document publicat a: https://doi.org/10.1136/jech-2019-212268
It is part of: Journal of Epidemiology and Community Health, 2020, vol. 74, num. 1, p. 26-31
URI: http://hdl.handle.net/2445/173022
Related resource: https://doi.org/10.1136/jech-2019-212268
ISSN: 0143-005X
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
699451.pdf257.55 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons