Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/173027
Title: Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
Author: Vitelli Storelli, Facundo
Zamora-Ros, Raul
Molina, Antonio J.
Fernández Villa, Tania
Castelló, Adela
Barrio, Juan Pablo
Amiano, Pilar
Ardanaz, Eva
Obón Santacana, Mireia
Gómez Acebo, Inés
Fernández Tardón, Guillermo
Molina Barceló, Ana
Alguacil, Juan
Marcos Gragera, Rafael
Ruiz Moreno, Emma
Pedraza, Manuela
Gil, Leire
Guevara, Marcela
Castaño-Vinyals, Gemma
Dierssen Sotos, Trinidad
Kogevinas, Manolis
Aragonès Sanz, Núria
Martín, Vicente
Keywords: Càncer de mama
Flavonoides
Polifenols
Breast cancer
Flavonoids
Polyphenols
Issue Date: 1-Apr-2020
Publisher: MDPI
Abstract: There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56-0.89, P-trend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59-0.93, P-trend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57-0.93; P-trend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.
Note: Reproducció del document publicat a: https://doi.org/10.3390/nu12040994
It is part of: Nutrients, 2020, vol. 12, num. 4
URI: http://hdl.handle.net/2445/173027
Related resource: https://doi.org/10.3390/nu12040994
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

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