Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/173043
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DC Field | Value | Language |
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dc.contributor.author | Dhillon, Poonam | - |
dc.contributor.author | Park, Jihwan | - |
dc.contributor.author | Hurtado del Pozo, Carmen | - |
dc.contributor.author | Li, Lingzhi | - |
dc.contributor.author | Doke, Tomohito | - |
dc.contributor.author | Huang, Shizheng | - |
dc.contributor.author | Zhao, Juanjuan | - |
dc.contributor.author | Kang, Hyun Mi | - |
dc.contributor.author | Shrestra, Rojesh | - |
dc.contributor.author | Balzer, Michael S. | - |
dc.contributor.author | Chatterjee, Shatakshee | - |
dc.contributor.author | Prado, Patricia | - |
dc.contributor.author | Han, Seung Yub | - |
dc.contributor.author | Liu, Hongbo | - |
dc.contributor.author | Sheng, Xin | - |
dc.contributor.author | Dierickx, Pieterjan | - |
dc.contributor.author | Batmanov, Kirill | - |
dc.contributor.author | Romero, Juan P. | - |
dc.contributor.author | Prósper, Felipe | - |
dc.contributor.author | Li, Mingyao | - |
dc.contributor.author | Pei, Liming | - |
dc.contributor.author | Kim, Junhyong | - |
dc.contributor.author | Montserrat, Núria | - |
dc.contributor.author | Susztak, Katalin | - |
dc.date.accessioned | 2021-01-08T18:27:13Z | - |
dc.date.available | 2021-12-09T06:10:19Z | - |
dc.date.issued | 2020-12-09 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173043 | - |
dc.description.abstract | Kidney disease is poorly understood because of the organ’s cellular diversity. We used single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular composition but also in cell-type-specific gene expression in mouse models of kidney disease. This analysis highlighted major changes in cellular diversity in kidney disease, which markedly impacted whole-kidney transcriptomics outputs. Cell-type-specific differential expression analysis identified proximal tubule (PT) cells as the key vulnerable cell type. Through unbiased cell trajectory analyses, we show that PT cell differentiation is altered in kidney disease. Metabolism (fatty acid oxidation and oxidative phosphorylation) in PT cells showed the strongest and most reproducible association with PT cell differentiation and disease. Coupling of cell differentiation and the metabolism was established by nuclear receptors (estrogen-related receptor alpha [ESRRA] and peroxisomal proliferation-activated receptor alpha [PPARA]) that directly control metabolic and PT-cell-specific gene expression in mice and patient samples while protecting from kidney disease in the mouse model. | ca |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.cmet.2020.11.011 | - |
dc.relation.ispartof | Cell Metabolism, 2020, vol. 33, num. 2, p. 379-394 | - |
dc.relation.uri | https://doi.org/10.1016/j.cmet.2020.11.011 | - |
dc.rights | (c) Elsevier Inc., 2020 | - |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Malalties del ronyó | - |
dc.subject.classification | RNA | - |
dc.subject.other | Kidney diseases | - |
dc.subject.other | RNA | - |
dc.title | The nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/640525/EU//REGMAMKID | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33301705 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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L20_2020_Cell Metabolism_X_X_OA.pdf | 11.96 MB | Adobe PDF | View/Open |
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