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http://hdl.handle.net/2445/173069
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DC Field | Value | Language |
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dc.contributor.author | Leurs, C. E. | - |
dc.contributor.author | Twaalfhoven, H. | - |
dc.contributor.author | Lissenberg-Witte, B. I. | - |
dc.contributor.author | van Pesch, V. | - |
dc.contributor.author | Dujmovic, Irena | - |
dc.contributor.author | Drulovic, J. | - |
dc.contributor.author | Castellazzi, M. | - |
dc.contributor.author | Bellini, T. | - |
dc.contributor.author | Pugliatti, M. | - |
dc.contributor.author | Kuhle, J. | - |
dc.contributor.author | Villar, Luisa M. | - |
dc.contributor.author | Álvarez Cermeño, José C. | - |
dc.contributor.author | Alvarez Lafuente, R. | - |
dc.contributor.author | Hegen, H. | - |
dc.contributor.author | Deisenhammer, F. | - |
dc.contributor.author | Walchhofer, L. M. | - |
dc.contributor.author | Thouvenot, E. | - |
dc.contributor.author | Comabella, Manuel | - |
dc.contributor.author | Montalbán Gairín, Xavier | - |
dc.contributor.author | Saiz Hinarejos, Albert | - |
dc.contributor.author | Puma, D. La | - |
dc.contributor.author | Vercammen, M. | - |
dc.contributor.author | Vanopdenbosch, L. | - |
dc.contributor.author | Uitdehaag, B. M. J. | - |
dc.contributor.author | Killestein, J. | - |
dc.contributor.author | Bridel, C. | - |
dc.contributor.author | Teunissen, C. | - |
dc.date.accessioned | 2021-01-11T14:15:43Z | - |
dc.date.available | 2021-01-11T14:15:43Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1352-4585 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173069 | - |
dc.description.abstract | Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mix- ture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI=4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | SAGE Publications | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1177/1352458519845844 | - |
dc.relation.ispartof | Multiple Sclerosis Journal, 2020, vol. 26, num. 8, p. 912-923 | - |
dc.relation.uri | https://doi.org/10.1177/1352458519845844 | - |
dc.rights | cc by-nc (c) Leurs et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Esclerosi múltiple | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.other | Multiple sclerosis | - |
dc.subject.other | Biochemical markers | - |
dc.title | Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 690300 | - |
dc.date.updated | 2021-01-11T14:15:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31066634 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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690300.pdf | 399.88 kB | Adobe PDF | View/Open |
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