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http://hdl.handle.net/2445/173093
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DC Field | Value | Language |
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dc.contributor.author | González Díaz, Aida | - |
dc.contributor.author | Machado, Miguel P | - |
dc.contributor.author | Cámara, Jordi | - |
dc.contributor.author | Yuste, José | - |
dc.contributor.author | Varon, Emmanuelle | - |
dc.contributor.author | Domenech, Miriam | - |
dc.contributor.author | Grosso, María Del | - |
dc.contributor.author | Marimón, José María | - |
dc.contributor.author | Cercenado, Emilia | - |
dc.contributor.author | Larrosa, Nieves | - |
dc.contributor.author | Quesada, María Dolores | - |
dc.contributor.author | Fontanals, Dionisia | - |
dc.contributor.author | El-Mniai, Assiya | - |
dc.contributor.author | Cubero, Meritxell | - |
dc.contributor.author | Carrico, João A. | - |
dc.contributor.author | Martí Martí, Sara | - |
dc.contributor.author | Ramirez, Mario | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.date.accessioned | 2021-01-13T16:54:23Z | - |
dc.date.available | 2021-01-13T16:54:23Z | - |
dc.date.issued | 2020-04-23 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173093 | - |
dc.description.abstract | Background: The successful pneumococcal clone Spain(9V)-ST156 (PMEN3) is usually associated with vaccine serotypes 9V and 14. Aim: Our objective was to analyse the increase of a serotype 11A variant of PMEN3 as cause of invasive pneumococcal disease (IPD) in Spain and its spread in south-western Europe. Methods: We conducted a prospective multicentre study of adult IPD in Spain (2008-16). Furthermore, a subset of 61 penicillin-resistant serotype 11A isolates from France, Italy, Portugal and Spain were subjected to whole genome sequencing (WGS) and compared with 238 genomes from the European Nucleotide Archive (ENA). Results: Although the incidence of serotype 11A in IPD was stable, a clonal shift was detected from CC62 (penicillin-susceptible) to CC156 (penicillin-resistant). By WGS, three major 11A-CC156 lineages were identified, linked to ST156 (n=5 isolates; France, Italy and Portugal), ST166 (n=4 isolates; France and Portugal) and ST838/6521 (n=52 isolates; France, Portugal and Spain). Acquisition of the capsule allowed to escape vaccine effect. AP200 (11A-ST62) was the donor for ST156 and ST838/6521 but not for ST166. In-depth analysis of ST838/6521 lineage showed two multi-fragment recombination events including four and seven fragments from an 11A-ST62 and an NT-ST344 representative, respectively. Conclusion: The increase in penicillin-resistant serotype 11A IPD in Spain was linked to the spread of a vaccine escape PMEN3 recombinant clone. Several recombination events were observed in PMEN3 acquiring an 11A capsule. The most successful 11A-PMEN3 lineage spreading in south-western Europe appeared after two multi-fragment recombination events with representatives of two major pneumococcal clones (11A-ST62 and NT-ST344). | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | European Centre for Disease Prevention and Control | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2807/1560-7917.ES.2020.25.16.1900457 | - |
dc.relation.ispartof | Eurosurveillance, 2020, vol. 25, num. 16, p. 42-51 | - |
dc.relation.uri | https://doi.org/10.2807/1560-7917.ES.2020.25.16.1900457 | - |
dc.rights | cc by (c) González Díaz et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Infeccions per pneumococs | - |
dc.subject.ddc | Vacunes | - |
dc.subject.other | Pneumococcal Infections | - |
dc.subject.other | Vaccines | - |
dc.title | Two multi-fragment recombination events resulted in the beta-lactam-resistant serotype 11A-ST6521 related to Spain9V-ST156 pneumococcal clone spreading in south-western Europe, 2008 to 2016 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 709402 | - |
dc.date.updated | 2020-12-21T13:10:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32347199 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Medicina) |
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709402.pdf | 1.1 MB | Adobe PDF | View/Open |
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