Please use this identifier to cite or link to this item:
Title: Psychosocial stress and epigenetic aging
Author: Palma-Gudiel, Helena
Fañanás Saura, Lourdes
Horvath, Steve
Zannas, Anthony S.
Keywords: Envelliment
Issue Date: 20-Nov-2019
Publisher: Elsevier
Abstract: Aging is the single most important risk factor for diseases that are currently the leading causes of morbidity and mortality. However, there is considerable inter-individual variability in risk for aging-related disease, and studies suggest that biological age can be influenced by multiple factors, including exposure to psychosocial stress. Among markers of biological age that can be affected by stress, the present article focuses on the so-called measures of epigenetic aging: DNA methylation-based age predictors that are measured in a range of tissues, including the brain, and can predict lifespan and healthspan. We review evidence linking exposure to diverse types of psychosocial stress, including early-life stress, cumulative stressful experiences, and low socioeconomic status, with accelerated epigenetic aging as a putative mediator of the effects of psychosocial environment on health and disease. The chapter also discusses methodological
Note: Versió postprint del document publicat a:
It is part of: International Review of Neurobiology, 2019, vol. 150, p. 107-128
Related resource:
ISSN: 0074-7742
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

Files in This Item:
File Description SizeFormat 
705566.pdf221.8 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.