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Title: Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Author: Harms, Laura M.
Scalbert, Augustin
Zamora-Ros, Raul
Rinaldi, Sabina
Jenab, Mazda
Murphy, Neil
Achaintre, David
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Mancini, Francesca Romana
Mahamat-Saleh, Yahya
Boutron-Ruault, Marie-Christine
Kühn, Tilman
Katzke, Verena
Trichopoulou, Antonia
Martimianaki, Georgia
Karakatsani, Anna
Palli, Domenico
Panico, Salvatore
Sieri, Sabina
Tumino, Rosario
Sacerdote, Carlotta
Bueno de Mesquita, H. Bas
Vermeulen, Roel C. H.
Weiderpass, Elisabete
Haugdahl Nøst, Therese
Lasheras, Cristina
Rodríguez Barranco, Miguel
Huerta Castaño, José María
Barricarte, Aurelio
Dorronsoro, Miren
Hultdin, Johan
Schmidt, Julie A.
Gunter, Marc J.
Riboli, Elio
Aleksandrova, Krasimira
Keywords: Polifenols
Malalties cròniques
Chronic diseases
Issue Date: 28-Jan-2020
Publisher: Cambridge University Press
Abstract: Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 % CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 % CI 50, 1) % lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0 center dot 66, 95 % CI 0 center dot 46, 0 center dot 96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0 center dot 58, 95 % CI 0 center dot 39, 0 center dot 86), 3,4-dihydroxyphenylpropionic acid (OR 0 center dot 63, 95 % CI 0 center dot 46, 0 center dot 87), ferulic acid (OR 0 center dot 65, 95 % CI 0 center dot 44, 0 center dot 96) and caffeic acid (OR 0 center dot 69, 95 % CI 0 center dot 51, 0 center dot 93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0 center dot 67, 95 % CI 0 center dot 48, 0 center dot 93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.
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It is part of: British Journal of Nutrition, 2020, vol. 123, num. 2, p. 198-208
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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