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Title: Diagnostic accuracy of prion disease biomarkers in iatrogenic Creutzfeldt-Jakob disease
Author: Llorens Torres, Franc
Villar Piqué, Anna
Hermann, Peter
Schmitz, Matthias
Calero, Olga
Stehmann, Christiane
Sarros, Shannon
Moda, Fabio
Ferrer, Isidro (Ferrer Abizanda)
Poleggi, Anna
Pocchiari, Maurizio
Catania, Marcella
Klotz, Sigrid
O'Regan, Carl
Brett, Francesca
Heffernan, Josephine
Ladogana, Anna
Collins, Steven J.
Calero, Miguel
Kovacs, Gabor G.
Zerr, Inga
Keywords: Malaltia de Creutzfeldt-Jakob
Marcadors bioquímics
Creutzfeldt-Jakob disease
Biochemical markers
Issue Date: 12-Feb-2020
Publisher: MDPI
Abstract: Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt-Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.
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It is part of: Biomolecules, 2020, vol. 10, num. 2
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ISSN: 2218-273X
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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