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http://hdl.handle.net/2445/173319
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DC Field | Value | Language |
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dc.contributor.author | Medina, Alejandro | - |
dc.contributor.author | Jiménez, Cristina | - |
dc.contributor.author | Sarasquete, M. Eugenia | - |
dc.contributor.author | González, Marcos | - |
dc.contributor.author | Chillón, M. Carmen | - |
dc.contributor.author | Balanzategui, Ana | - |
dc.contributor.author | Prieto Conde, Isabel | - |
dc.contributor.author | García Álvarez, María | - |
dc.contributor.author | Puig, Noemí | - |
dc.contributor.author | González Calle, Verónica | - |
dc.contributor.author | Alcoceba, Miguel | - |
dc.contributor.author | Cuenca, Isabel | - |
dc.contributor.author | Barrio, Santiago | - |
dc.contributor.author | Escalante, Fernando | - |
dc.contributor.author | Gutiérrez, Norma C. | - |
dc.contributor.author | Gironella, Mercedes | - |
dc.contributor.author | Hernández, Miguel T. | - |
dc.contributor.author | Sureda, Anna | - |
dc.contributor.author | Oriol, Albert | - |
dc.contributor.author | Bladé, J. (Joan) | - |
dc.contributor.author | Lahuerta, Juan José | - |
dc.contributor.author | San Miguel, Jesús F. | - |
dc.contributor.author | Mateos, María Victoria | - |
dc.contributor.author | Martínez López, Joaquín | - |
dc.contributor.author | Calasanz, María José | - |
dc.contributor.author | García Sanz, Ramón | - |
dc.date.accessioned | 2021-01-21T13:05:17Z | - |
dc.date.available | 2021-01-21T13:05:17Z | - |
dc.date.issued | 2020-02-06 | - |
dc.identifier.issn | 2044-5385 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173319 | - |
dc.description.abstract | Multiple myeloma is a heterogeneous disease whose pathogenesis has not been completely elucidated. Although B-cell receptors play a crucial role in myeloma pathogenesis, the impact of clonal immunoglobulin heavy-chain features in the outcome has not been extensively explored. Here we present the characterization of complete heavy-chain gene rearrangements in 413 myeloma patients treated in Spanish trials, including 113 patients characterized by next-generation sequencing. Compared to the normal B-cell repertoire, gene selection was biased in myeloma, with significant overrepresentation of IGHV3, IGHD2 and IGHD3, as well as IGHJ4 gene groups. Hypermutation was high in our patients (median: 8.8%). Interestingly, regarding patients who are not candidates for transplantation, a high hypermutation rate (≥7%) and the use of IGHD2 and IGHD3 groups were associated with improved prognostic features and longer survival rates in the univariate analyses. Multivariate analysis revealed prolonged progression-free survival rates for patients using IGHD2/IGHD3 groups (HR: 0.552, 95% CI: 0.361−0.845, p = 0.006), as well as prolonged overall survival rates for patients with hypermutation ≥7% (HR: 0.291, 95% CI: 0.137−0.618, p = 0.001). Our results provide new insights into the molecular characterization of multiple myeloma, highlighting the need to evaluate some of these clonal rearrangement characteristics as new potential prognostic markers. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41408-020-0283-8 | - |
dc.relation.ispartof | Blood Cancer Journal, 2020, vol. 10, num. 14 | - |
dc.relation.uri | https://doi.org/10.1038/s41408-020-0283-8 | - |
dc.rights | cc-by (c) Medina, Alejandro et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Mieloma múltiple | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.other | Multiple myeloma | - |
dc.subject.other | B cells | - |
dc.title | Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 700354 | - |
dc.date.updated | 2021-01-21T13:05:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32029700 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Clíniques) |
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