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http://hdl.handle.net/2445/173364
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DC Field | Value | Language |
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dc.contributor.author | Camarero, Núria | - |
dc.contributor.author | Trapero, Ana | - |
dc.contributor.author | Pérez Jiménez, Ariadna | - |
dc.contributor.author | Macia, Eric | - |
dc.contributor.author | Gomila Juaneda, Alexandre | - |
dc.contributor.author | Gorostiza Langa, Pablo Ignacio | - |
dc.contributor.author | Nevola, Laura | - |
dc.contributor.author | Llobet Berenguer, Artur, 1972- | - |
dc.contributor.author | Llebaria, Amadeu | - |
dc.contributor.author | Hernando, Jordi | - |
dc.contributor.author | Giralt Lledó, Ernest | - |
dc.date.accessioned | 2021-01-25T10:20:47Z | - |
dc.date.available | 2021-01-25T10:20:47Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173364 | - |
dc.description.abstract | The spatiotemporal control of cellular dynamic processes has great fundamental interest but lacks versatile molecular tools. Dynamin is a key protein in endocytosis and an appealing target to manipulate cell trafficking using patterns of light. We have developed the first photoswitchable small-molecule inhibitors of endocytosis (dynazos), by a stepwise design of the photochromic and pharmacological properties of dynasore, a dynamin inhibitor. We have characterized their photochromism with UV-visible and transient absorption spectroscopy and their biological activity using fluorescence microscopies and flow cytometry. Dynazos are water-soluble, cell permeable, and photostable, and enable fast, single- wavelength photoswitchable inhibition of clathrin-mediated endocytosis at micromolar concentration. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1039/d0sc03820b | - |
dc.relation.ispartof | Chemical Science, 2020, vol. 11, p. 8981-8988 | - |
dc.relation.uri | https://doi.org/10.1039/d0sc03820b | - |
dc.rights | (c) Camarero, Núria et al., 2020 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Interacció cel·lular | - |
dc.subject.classification | Espectroscòpia molecular | - |
dc.subject.other | Cell interaction | - |
dc.subject.other | Molecular spectroscopy | - |
dc.title | Photoswitchable dynasore analogs to control endocytosis with light | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 703957 | - |
dc.date.updated | 2021-01-25T10:20:47Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/945539/EU//HBP SGA3 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33016959 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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703957.pdf | 758.67 kB | Adobe PDF | View/Open |
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