Please use this identifier to cite or link to this item:
Title: Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors
Author: Serrano Novillo, Clara
Oliveras, Anna
Ferreres, Joan Carles
Condom i Mundó, Enric
Felipe Campo, Antonio
Keywords: Tumors
Vasos sanguinis
Blood vessels
Issue Date: 1-Sep-2020
Publisher: MDPI
Abstract: Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cell cycle progression and proliferation. Kv channel remodeling has been associated with neoplastic cell growth and cancer. Kv7 channels are expressed in blood vessels, and they participate in the maintenance of vascular tone and are implicated in myocyte proliferation. Although evidence links Kv7 remodeling to different types of cancer, its expression in vascular tumors has never been studied. Endothelium-derived vascular neoplasms range from indolent lesions to highly aggressive and metastasizing cancers. Here, we show that Kv7.1 and Kv7.5 are evenly distributed in tunicas as well as the endothelium of healthy veins and arteries. The layered structure of vessels is lost in vascular tumors. By studying eight vascular tumors with different origins and characteristics, we found that Kv7.1 and Kv7.5 expression was changed in vascular cancers. While both channels were generally downregulated, Kv7.5 expression was clearly correlated with neoplastic malignancy. The vascular tumors did not contract; therefore, the role of Kv7 channels is probably related to proliferation rather than controlling vascular tone. Our results identify vascular Kv7 channels as targets for cancer detection and anticancer therapies.
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2020, vol. 21, num. 17
Related resource:
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
Serrano-NovilloC.pdf2.84 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons