Por favor, use este identificador para citar o enlazar este documento: https://hdl.handle.net/2445/173463
Título: Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors
Autor: Serrano Novillo, Clara
Oliveras Martínez, Anna
Ferreres, Joan Carles
Condom i Mundó, Enric
Felipe Campo, Antonio
Materia: Tumors
Càncer
Vasos sanguinis
Tumors
Cancer
Blood vessels
Fecha de publicación: 1-sep-2020
Publicado por: MDPI
Resumen: Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cell cycle progression and proliferation. Kv channel remodeling has been associated with neoplastic cell growth and cancer. Kv7 channels are expressed in blood vessels, and they participate in the maintenance of vascular tone and are implicated in myocyte proliferation. Although evidence links Kv7 remodeling to different types of cancer, its expression in vascular tumors has never been studied. Endothelium-derived vascular neoplasms range from indolent lesions to highly aggressive and metastasizing cancers. Here, we show that Kv7.1 and Kv7.5 are evenly distributed in tunicas as well as the endothelium of healthy veins and arteries. The layered structure of vessels is lost in vascular tumors. By studying eight vascular tumors with different origins and characteristics, we found that Kv7.1 and Kv7.5 expression was changed in vascular cancers. While both channels were generally downregulated, Kv7.5 expression was clearly correlated with neoplastic malignancy. The vascular tumors did not contract; therefore, the role of Kv7 channels is probably related to proliferation rather than controlling vascular tone. Our results identify vascular Kv7 channels as targets for cancer detection and anticancer therapies.
Nota: Reproducció del document publicat a: https://doi.org/10.3390/ijms21176019
Es parte de: International Journal of Molecular Sciences, 2020, vol. 21, num. 17
URI: https://hdl.handle.net/2445/173463
Recurso relacionado: https://doi.org/10.3390/ijms21176019
Aparece en las colecciones:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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