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http://hdl.handle.net/2445/173506
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DC Field | Value | Language |
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dc.contributor.author | Demontis, Ditte | - |
dc.contributor.author | Walters, Raymond | - |
dc.contributor.author | Rajagopal, Veera M. | - |
dc.contributor.author | Waldman, Irwin D. | - |
dc.contributor.author | Grove, Jakob | - |
dc.contributor.author | Als, Thomas D. | - |
dc.contributor.author | Dalsgaard, Soren | - |
dc.contributor.author | Ribasés Haro, Marta | - |
dc.contributor.author | Grauholm, Jonas | - |
dc.contributor.author | Bækvad-Hansen, Maria | - |
dc.contributor.author | Werge, Thomas | - |
dc.contributor.author | Nordentoft, Merete | - |
dc.contributor.author | Mors, Ole | - |
dc.contributor.author | Mortensen, Preben Bo | - |
dc.contributor.author | Psychiatric Genomics Consortium (PGC) | - |
dc.contributor.author | Cormand Rifà, Bru | - |
dc.contributor.author | Hougaard, David M. | - |
dc.contributor.author | Neale, Benjamin M. | - |
dc.contributor.author | Franke, Barbara | - |
dc.contributor.author | Faraone, Stephen V. | - |
dc.contributor.author | Børglum, Anders D. | - |
dc.date.accessioned | 2021-01-28T15:35:17Z | - |
dc.date.available | 2021-01-28T15:35:17Z | - |
dc.date.issued | 2021-01-25 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173506 | - |
dc.description.abstract | Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10-10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-20443-2 | - |
dc.relation.ispartof | Nature Communications, 2021, vol. 12, num. 1, p. 576 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-020-20443-2 | - |
dc.rights | cc-by (c) Demontis, Ditte et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Trastorns per dèficit d'atenció amb hiperactivitat en els infants | - |
dc.subject.classification | Agressivitat en els infants | - |
dc.subject.other | Attention deficit disorder with hyperactivity in children | - |
dc.subject.other | Aggressiveness in children | - |
dc.title | Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 699382 | - |
dc.date.updated | 2021-01-28T15:35:17Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/602805/EU//AGGRESSOTYPE | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/667302/EU//CoCA | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/728018/EU//Eat2beNICE | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33495439 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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File | Description | Size | Format | |
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699382.pdf | 1.05 MB | Adobe PDF | View/Open |
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