Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/173550
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fenaroli, Federico | - |
dc.contributor.author | Robertson, James D. | - |
dc.contributor.author | Scarpa, Edoardo | - |
dc.contributor.author | Gouveia, Virginia M. | - |
dc.contributor.author | Guglielmo, Claudia Di | - |
dc.contributor.author | Pace, Cesare De | - |
dc.contributor.author | Elks, Philiip M. | - |
dc.contributor.author | Poma, Alessandro | - |
dc.contributor.author | Evangelopoulos, Dimitrios | - |
dc.contributor.author | Ortiz, Julio | - |
dc.contributor.author | Prajsnar, Tomasz K. | - |
dc.contributor.author | Marriott, Helen M. | - |
dc.contributor.author | Dockrell, David H. | - |
dc.contributor.author | Foster, Simon J. | - |
dc.contributor.author | McHugh, Timothy D. | - |
dc.contributor.author | Renshaw, Stephen A. | - |
dc.contributor.author | Samitier i Martí, Josep | - |
dc.contributor.author | Battaglia, Giuseppe | - |
dc.contributor.author | Rizzello, Loris | - |
dc.date.accessioned | 2021-01-30T09:17:45Z | - |
dc.date.available | 2021-06-09T05:10:24Z | - |
dc.date.issued | 2020-06-09 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173550 | - |
dc.description.abstract | Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favoring chronic and/or disseminated infection. One of the most infamous is the bacteria that cause tuberculosis (TB), which is the most pandemic and one of the deadliest diseases, with one-third of the world’s population infected and an average of 1.8 million deaths/year worldwide. Here we demonstrate the effective targeting and intracellular delivery of antibiotics to infected macrophages both in vitro and in vivo, using pH-sensitive nanoscopic polymersomes made of PMPC–PDPA block copolymer. Polymersomes showed the ability to significantly enhance the efficacy of the antibiotics killing Mycobacterium bovis, Mycobacterium tuberculosis, and another established intracellular pathogen, Staphylococcus aureus. Moreover, they demonstrated to easily access TB-like granuloma tissues—one of the harshest environments to penetrate—in zebrafish models. We thus successfully exploited this targeting for the effective eradication of several intracellular bacteria, including M. tuberculosis, the etiological agent of human TB. | ca |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | American Chemical Society | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acsnano.0c01870 | - |
dc.relation.ispartof | ACS Nano, 2020, vol. 14, num. 7, p. 8287-8298 | - |
dc.relation.uri | https://doi.org/10.1021/acsnano.0c01870 | - |
dc.rights | (c) American Chemical Society, 2020 | - |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Microorganismes patògens | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.classification | Peix zebra | - |
dc.subject.other | Pathogenic microorganisms | - |
dc.subject.other | Tuberculosis | - |
dc.subject.other | Zebra danio | - |
dc.title | Polymersomes eradicating intracellular bacteria | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/795224/EU//PHANTOM | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32515944 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
L05_2020_ACS Nano_14_8287_OA.pdf | 6.17 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.