Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/173838
Title: Interplay between humoral and CLA+ T cell response against Candida albicans in psoriasis
Author: de Jesús-Gil, Carmen
Sans-de San Nicolàs, Lídia
Ruiz-Romeu, Ester
Ferran, Marta
Soria-Martínez, Laura
García-Jiménez, Irene
Chiriac, Anca
Casanova-Seuma, Josep Manel
Fernández-Armenteros, Josep Manel
Sherry, Owens
Celada Cotarelo, Antonio
Howell, Michael D.
Pujol, Ramòn Maria
Santamaria-Babí, Luis Francisco
Keywords: Candida albicans
Psoriasi
Candida albicans
Psoriasis
Issue Date: 2-Feb-2021
Publisher: MDPI
Abstract: Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA􀀀 cutaneous lymphocyte antigen (CLA)+/􀀀 T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients.
Note: Reproducció del document publicat a: https://doi.org/10.3390/ijms22041519
It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 4, p. 1519
URI: http://hdl.handle.net/2445/173838
Related resource: https://doi.org/10.3390/ijms22041519
ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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