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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Rezvani, Maryam | - |
| dc.contributor.author | Manca, Maria Letizia | - |
| dc.contributor.author | Caddeo, Carla | - |
| dc.contributor.author | Escribano Ferrer, Elvira | - |
| dc.contributor.author | Carbone, Claudia | - |
| dc.contributor.author | Peris, José Esteban | - |
| dc.contributor.author | Usach, Iris | - |
| dc.contributor.author | Diez-Sales, Octavio | - |
| dc.contributor.author | Fadda, Anna Maria | - |
| dc.contributor.author | Manconi, Maria | - |
| dc.date.accessioned | 2021-02-11T10:30:10Z | - |
| dc.date.available | 2021-02-11T10:30:10Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.issn | 1999-4923 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/173852 | - |
| dc.description.abstract | The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit® L100), a water-soluble prebiotic fibre (Nutriose® FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit® and Nutriose® on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan® technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation. Keywords: Eudragit, Nutriose, phospholipid vesicles, antioxidant, intestinal wound healing | - |
| dc.format.extent | 10 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | MDPI | - |
| dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics11010013 | - |
| dc.relation.ispartof | Pharmaceutics, 2019, vol. 11, p. 13-22 | - |
| dc.relation.uri | https://doi.org/10.3390/pharmaceutics11010013 | - |
| dc.rights | cc-by (c) Rezvani, Maryam et al., 2019 | - |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
| dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
| dc.subject.classification | Vitamina C | - |
| dc.subject.classification | Vitamina E | - |
| dc.subject.classification | Cicatrització | - |
| dc.subject.classification | Intestins | - |
| dc.subject.classification | Neuroimmunologia | - |
| dc.subject.other | Vitamin C | - |
| dc.subject.other | Vitamin E | - |
| dc.subject.other | Wound healing | - |
| dc.subject.other | Intestines | - |
| dc.subject.other | Neuroimmunology | - |
| dc.title | Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.identifier.idgrec | 683802 | - |
| dc.date.updated | 2021-02-11T10:30:10Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| dc.identifier.pmid | 30621127 | - |
| Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 683802.pdf | 1.89 MB | Adobe PDF | View/Open |
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