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Title: Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Author: Bonaterra Pastra, Anna
Fernández de Retana, Sofia
Rivas Urbina, Andrea
Puig, Núria
Benítez, Sònia
Pancorbo, Olalla
Rodríguez Luna, David
Pujadas, Francesc
Freijo, Maria del Mar
Tur, Silvia
Martínez Zabaleta, Maite
Cardona Portela, Pere
Vera, Rocío
Lebrato Hernández, Lucia
Arenillas, Juan F.
Pérez Sánchez, Soledad
Montaner, Joan
Sánchez Quesada, Jose Luis
Hernández Guillamon, Mar
Keywords: Malaltia d'Alzheimer
Alzheimer's disease
Issue Date: 12-Jan-2021
Publisher: MDPI AG
Abstract: Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.
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It is part of: Biomedicines, 2021, vol. 9 (1), num. 72
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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