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http://hdl.handle.net/2445/173948
Title: | Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19) |
Author: | Pastick, Katelyn A. Okafor, Elizabeth C. Wang, Fan Lofgren, Sarah M. Skipper, Caleb P. Nicol, Melanie R. Pullen, Matthew F. Rajasingham, Radha McDonald, Emily G Lee, Todd C. Schwartz, Ilan S. Kelly, Lauren E. Lother, Sylvain A. Mitjà Villar, Oriol Letang, Emilio Abassi, Mahsa Boulware, David R. |
Keywords: | SARS-CoV-2 Parasitologia mèdica SARS-CoV-2 Medical parasitology |
Issue Date: | 15-Apr-2020 |
Publisher: | Oxford University Press; Infectious Diseases Society of America |
Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing in vitro and clinical studies. We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1093/ofid/ofaa130 |
It is part of: | Open Forum Infectious Diseases, 2020, vol. 7, num. 4 |
URI: | http://hdl.handle.net/2445/173948 |
Related resource: | http://dx.doi.org/10.1093/ofid/ofaa130 |
ISSN: | 2328-8957 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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Pastik_KA_Open_Forum_Infect_Dis_2020.pdf | 207.42 kB | Adobe PDF | View/Open |
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