Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/173968
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hernández González, Fernanda | - |
dc.contributor.author | Prieto González, Sergio | - |
dc.contributor.author | Brito Zerón, María del Pilar | - |
dc.contributor.author | Cuerpo, Sandra | - |
dc.contributor.author | Sánchez, Marcelo | - |
dc.contributor.author | Ramírez Ruz, J. (José) | - |
dc.contributor.author | Agustí García-Navarro, Carles | - |
dc.contributor.author | Lucena, Carmen M. | - |
dc.contributor.author | Paradela, Marina | - |
dc.contributor.author | Grafia, Ignacio | - |
dc.contributor.author | Espinosa Garriga, Gerard | - |
dc.contributor.author | Sellarés, Jacobo | - |
dc.date.accessioned | 2021-02-15T15:48:50Z | - |
dc.date.available | 2021-02-15T15:48:50Z | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173968 | - |
dc.description.abstract | To date, there is no clear agreement regarding which is the best method to detect a connective tissue disease (CTD) during the initial diagnosis of interstitial lung diseases (ILD). The aim of our study was to explore the impact of a systematic diagnostic strategy to detect CTD-associated ILD (CTD-ILD) in clinical practice, and to clarify the significance of interstitial pneumonia with autoimmune features (IPAF) diagnosis in ILD patients. Consecutive patients evaluated in an ILD Diagnostic Program were divided in 3 groups: IPAF, CTD-ILD, and other ILD forms. Clinical characteristics, exhaustive serologic testing, high resolution computed tomography (HRCT) images, lung biopsy specimens, and follow-up were prospectively collected and analyzed. Among 139 patients with ILD, CTD was present in 21 (15.1%), 24 (17.3%) fulfilled IPAF criteria, and 94 (67.6%) were classified as other ILD forms. Specific systemic autoimmune symptoms such as Raynaud phenomenon (19%), inflammatory arthropathy (66.7%), and skin manifestations (38.1%) were more frequent in CTD-ILD patients than in the other groups (all P< .001). Among autoantibodies, antinuclear antibody was the most frequently found in IPAF (42%), and CTD-ILD (40%) (P= .04). Nonspecific interstitial pneumonia, detected by HRCT scan, was the most frequently seen pattern in patients with IPAF (63.5%), or CTD-ILD (57.1%) (P< .001). In multivariate analysis, a suggestive radiological pattern by HRCT scan (odds ratio [OR] 15.1, 95% confidence interval [CI] 4.7-48.3, P< .001) was the strongest independent predictor of CTD-ILD or IPAF, followed by the presence of clinical features (OR 14.6, 95% CI 4.3-49.5, P< .001), and serological features (OR 12.4, 95% CI 3.5-44.0, P< .001). This systematic diagnostic strategy was useful in discriminating an underlying CTD in patients with ILD. The defined criteria for IPAF are fulfilled by a considerable proportion of patients referred for ILD. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Lippincott, Williams & Wilkins. Wolters Kluwer Health | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000018589 | - |
dc.relation.ispartof | Medicine, 2020, vol. 99, num. 4, p. e18589 | - |
dc.relation.uri | https://doi.org/10.1097/MD.0000000000018589 | - |
dc.rights | cc-by (c) Hernández González, Fernanda et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Malalties del pulmó | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.other | Pulmonary diseases | - |
dc.subject.other | Diagnosis | - |
dc.subject.other | Autoimmune diseases | - |
dc.title | Impact of a systematic evaluation of connective tissue disease on diagnosis approach in patients with interstitial lung diseases | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 707025 | - |
dc.date.updated | 2021-02-15T15:48:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31977850 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707025.pdf | 544.63 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License