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http://hdl.handle.net/2445/174017
Title: | Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality |
Author: | Martínez López, Joaquín Mateos, María Victoria Encinas, Cristina Sureda, Anna Hernández Rivas, José Ángel López de la Guía, Ana Conde, Diego Krsnik, Isabel Prieto, Elena Riaza Grau, Rosalía Gironella, Mercedes Blanchard, María Jesús Caminos, Nerea Fernández de Larrea Rodríguez, Carlos José Senin, María Alicia Escalante, Fernando Puerta, José Enrique de la Giménez, Eugenio Martínez Barranco, Pilar Mateos, Juan José Casado, Luis Felipe Bladé, J. (Joan) Lahuerta, Juan José San Miguel, Jesús |
Keywords: | COVID-19 Pronòstic mèdic Mieloma múltiple COVID-19 Prognosis Multiple myeloma |
Issue Date: | 19-Oct-2020 |
Publisher: | Springer Nature |
Abstract: | There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiplemyeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes werecompared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admittedat six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients weremale; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity wasmoderate-severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was requiredby 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasiveventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients,inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM athospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independentprognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifiespredictors of inpatient mortality among MM patients hospitalized with COVID-19. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41408-020-00372-5 |
It is part of: | Blood Cancer Journal, 2020, vol. 10, num. 103 |
URI: | http://hdl.handle.net/2445/174017 |
Related resource: | https://doi.org/10.1038/s41408-020-00372-5 |
ISSN: | 2044-5385 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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