Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/174062
Title: | HPV Vaccination as Adjuvant to Conization in Women with Cervical Intraepithelial Neoplasia: A Study under Real-Life Conditions |
Author: | Pino Saladrigues, Marta del Martí, Cristina Torras, Ines Henere, Carla Munmany, Meritxell Marimon, Lorena Saco, Adela Torné Bladé, Aureli Ordi i Majà, Jaume |
Keywords: | Vacuna del papil·lomavirus Tumors Papillomavirus vaccines Tumors |
Issue Date: | 23-May-2020 |
Publisher: | MDPI |
Abstract: | Background: Recent studies have shown preliminary evidence that vaccination against human papillomavirus (HPV) could decrease the risk of persistent/recurrent HSIL in women treated for high-grade cervical intraepithelial lesion (HSIL). We aimed to determine the benefits of HPV vaccination in patients undergoing conization for HSIL in real-life conditions and evaluate vaccination compliance associated with different funding policies. Methods: From January 2013 to July 2018, 265 women underwent conization in our center. From January 2013 to July 2017, treated patients (n = 131) had to pay for the vaccine, whereas after July 2017 the vaccine was publicly funded and free for treated women (n = 134). Post-conization follow-up controls were scheduled every six months with a Pap smear, HPV testing, and a colposcopy. Results: 153 (57.7%) women accepted vaccination (vaccinated group), and 112 (42.3%) refused the vaccine (non-vaccinated group). Persistent/recurrent HSIL was less frequent in vaccinated than in non-vaccinated women (3.3% vs. 10.7%, p = 0.015). HPV vaccination was associated with a reduced risk of persistent/recurrent HSIL (OR 0.2, 95%CI: 0.1–0.7, p = 0.010). Vaccination compliance increased when the vaccine was publicly funded (from 35.9% [47/131] to 79.1% [106/134], p < 0.001). Conclusions: HPV vaccination in women undergoing conization is associated with a 4.5-fold reduction in the risk of persistent/recurrent HSIL. Vaccination policies have an important impact on vaccination compliance. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3390/vaccines8020245 |
It is part of: | Vaccines, 2020, vol. 8, num. 2 |
URI: | http://hdl.handle.net/2445/174062 |
Related resource: | http://dx.doi.org/10.3390/vaccines8020245 |
ISSN: | 2076-393X |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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Del_Pino_M_Vaccines_Basel_2020.pdf | 596.22 kB | Adobe PDF | View/Open |
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